Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 491-500 of 730 results
Journal of Extracellular Vesicles, 2022 • March 2, 2022
This study investigates the functional role of the protein corona surrounding extracellular vesicles (EVs) derived from human placental-expanded (PLX) stromal cells. The researchers found that this co...
KEY FINDING: PLX-EVs are surrounded by a functional protein corona when enriched with permissive technology, containing immunomodulatory and proangiogenic proteins.
Frontiers in Immunology, 2022 • March 24, 2022
This study explores the therapeutic potential of TnP, a synthetic peptide derived from fish venom, in treating multiple sclerosis (MS) using the experimental autoimmune encephalomyelitis (EAE) mouse m...
KEY FINDING: Prophylactic treatment with TnP offered similar protection to betaseron and better protection than glatiramer or fingolimod against the development of clinical symptoms in the EAE model.
J. Clin. Med., 2022 • April 11, 2022
The study investigated the effects of pre- and postconditioning with a TLR3 agonist (poly(I:C)) or shock wave therapy (SWT) on spinal cord ischemia (SCI) in cultured SHSY-5Y cells. TLR3 activation wit...
KEY FINDING: TLR3 activation via poly(I:C) significantly reduced apoptotic markers in both pre- and postconditioning, with preconditioning yielding more favorable results due to additional suppression of TLR4 signaling.
Journal of Neuroinflammation, 2022 • April 7, 2022
This study investigates the therapeutic potential of macrophage-based delivery of interleukin-13 (IL-13) to improve functional and histopathological outcomes following spinal cord injury (SCI) in mice...
KEY FINDING: Transplantation of IL-13 Mφs promoted functional recovery following SCI in mice, indicated by significantly improved Basso Mouse Scale (BMS) scores compared to vehicle and M2 Mφ groups.
Frontiers in Cell and Developmental Biology, 2022 • April 13, 2022
The editorial provides an overview of the recent advancements in parasitic disease control by utilizing novel tools and methodologies developed in genomic, epigenomic, proteomics, and metabolomics res...
KEY FINDING: High-quality genome assembly of Moniezia expansa reveals potential target molecules for treating parasitic diseases through the identification of specific fatty acid metabolism and reproductive stem cell regulatory networks.
Cell Death and Disease, 2022 • May 12, 2022
This study used single-cell RNA sequencing to analyze immune cell dynamics after spinal cord injury (SCI) in mice, revealing the heterogeneity of immune cells and the repopulation of microglia. The re...
KEY FINDING: Microglia repopulation after SCI is primarily derived from residual microglia, not from nestin+ stem cells.
Exp Neurol, 2022 • September 1, 2022
This study investigated the role of glucocorticoid receptors (GRs) in myeloid cells after spinal cord injury (SCI). Contrary to the hypothesis that deleting GR would worsen outcomes, the study found t...
KEY FINDING: Deleting GR in myeloid cells (macrophages and microglia) reduced the inflammatory response in the spinal cord after injury.
Disease Markers, 2022 • May 11, 2022
The study investigates the role of DYNC1H1 in LIHC using bioinformatics and experimental analysis, finding that DYNC1H1 expression is associated with clinicopathological features and poor prognosis. G...
KEY FINDING: DYNC1H1 expression levels were associated with T classification, pathologic stage, histologic grade, and serum AFP levels in LIHC patients.
Diagnostics, 2022 • May 10, 2022
The study addresses the need for a sample storage buffer (SSB) that inactivates SARS-CoV-2 while preserving viral RNA for reliable diagnostics and sequencing. The developed guanidine-hydrochloride-bas...
KEY FINDING: The guanidine-hydrochloride-based storage buffer (SSB-4M) is compatible with commercially available and in-house GuHCl-based RNA extraction methods.
Frontiers in Immunology, 2022 • May 30, 2022
The study characterized two populations of intraperitoneal zymosan-modulated Ly6G+ neutrophils, revealing that 3d NF exhibit features of alternative activation, an immature stage of development, and n...
KEY FINDING: 3d NF expressed markers of alternative activation and possess neuroprotective/ regenerative properties.