Immunology Research

KEY FINDING: MSCs can regulate macrophage polarization, shifting the balance from pro-inflammatory M1 to anti-inflammatory M2 phenotypes, which promotes axonal regeneration and reduces glial scar formation.

KEY FINDING: ADSC-Exos significantly promoted DPC proliferation and migration while also reducing apoptosis in vitro.

KEY FINDING: m5C mRNA methylation is strikingly enhanced in the transcriptomes of gametocytes in both Plasmodium yoelii and Plasmodium falciparum.

KEY FINDING: The tadpole skin microbiome varies significantly between sibships and is altered by raising tadpoles in the antibiotic gentamicin.

KEY FINDING: Eight heterochromatin-associated ApiAP2 transcription factors (PfAP2-HFs) were identified, showing preferential enrichment within heterochromatic regions but with differential coverage profiles.

KEY FINDING: IL10-MSC treatment markedly reinforced locomotor improvement, accompanied with decreased lesion volume, regeneration of axons, and preservation of neurons, compared with naïve unmodified MSCs.

KEY FINDING: NLRP3 inflammasome components are markedly upregulated in the L4–L5 segments of the spinal cord in the first 3 days after sciatic nerve injury.

KEY FINDING: Deletion of TLR2 or TLR4 significantly reduced the number of Sox2-expressing NPCs in the neonatal mouse spinal cord, indicating a role in maintaining the neural progenitor population.

KEY FINDING: Anti-N antibody levels decline over one year post-infection, while anti-S antibody levels remain stable.

KEY FINDING: C3 expression rapidly increased in the optic nerve after crush injury, followed by a steady increase in C1q expression. CR3+ cells increased from 1 day post-injury up to 14 days.