Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 501-510 of 730 results
Glia, 2022 • October 1, 2022
This study demonstrates the capacity of digoxin to induce OPC differentiation in vitro, to robustly stimulate myelination in vivo in the chemically-induced cuprizone and lysophosphatidylcholine (LPC) ...
KEY FINDING: Digoxin regulated multiple genes in oligodendrocyte progenitor cells (OPCs) essential for oligodendrocyte (OL) differentiation in vitro, promoted OL differentiation both in vitro and in vivo in female naïve C57BL/6J (B6) mice, and stimulated recovery of myelinated axons in B6 mice following demyelination in the corpus callosum induced by cuprizone and spinal cord demyelination induced by lysophosphatidylcholine (LPC), respectively.
Nature Communications, 2022 • July 21, 2022
This study demonstrates that microglia are vital for SCI recovery and coordinate injury responses in CNS-resident glia and infiltrating leukocytes. The research identifies specific signaling axes depe...
KEY FINDING: Microglia depletion exacerbates tissue damage and worsens functional recovery after SCI in mice.
Cellular & Molecular Biology Letters, 2022 • September 2, 2022
This study investigates the evolutionary dynamics and function of progranulins (PGRNs) in lampreys, primitive vertebrates known for their regenerative abilities. Four genes encoding PGRNs were identif...
KEY FINDING: Four PGRN genes were identified in lampreys: one long form (Lr-PGRN-L) and three short forms (Lr-PGRN-S1, Lr-PGRN-S2, and Lr-PGRN-S3).
VIEW, 2022 • March 2, 2022
This study reveals that acidosis-related pH promotes SARS-CoV-2 infection by increasing ACE2 expression on the cell membrane, suggesting a positive feedback loop where SARS-CoV-2 infection-induced aci...
KEY FINDING: Acidosis-related pH (6.8) increases the expression of SARS-CoV-2 receptor ACE2 on the cell membrane.
Dev Cell, 2024 • February 26, 2024
The study dissects macrophage phenotypes in spiny mice (Acomys spp.) that regenerate ear pinnae tissue versus lab mice (Mus musculus) that form scar tissue, identifying secreted factors from activated...
KEY FINDING: Acomys macrophages exhibit a muted inflammatory profile compared to Mus macrophages and secrete factors that antagonize collagen production and drive matrix remodeling.
PLoS Biology, 2022 • August 26, 2022
This study demonstrates that the antimicrobial peptide cathelicidin drives severe autoimmune disease in the mouse model of MS. Exposure of CD4+ T cells in the draining lymph node to neutrophil-derived...
KEY FINDING: Cathelicidin is expressed by multiple cell types in lymphoid organs and the central nervous system during EAE, including neutrophils, endothelial cells and microglia/macrophages.
Current Neuropharmacology, 2023 • January 1, 2023
This review summarizes the mechanisms by which neuroinflammation, mediated by the NLRP3 inflammasome, exacerbates secondary white matter injury (WMI) after intracerebral hemorrhage (ICH). The review d...
KEY FINDING: White matter injury (WMI) significantly contributes to neurological dysfunction after intracerebral hemorrhage (ICH), often more than previously recognized gray matter injuries.
FEBS Open Bio, 2022 • January 1, 2022
This study identifies differentially-expressed innate immune-related genes and hub genes following spinal cord injury (SCI). Temporal expression patterns of these genes were analyzed and validated to ...
KEY FINDING: Nine hub genes (Ccl2, Stat3, Mapk14, Stat1, Tlr2, Cxcl10, Myd88, Itgam, and Mapk8) were identified as key players in the innate immune response after SCI.
Acta Neuropathologica, 2022 • September 16, 2022
The study generated an integrated cell type-specific transcriptomic atlas of MS pathology spanning three major CNS sites including leukocortical, cerebellar and spinal cord areas. The study identified...
KEY FINDING: While we found strong cross-regional diversity among glial subtypes in control tissue, regional signatures become more obscure in MS.
The Journal of Immunology, 2022 • September 15, 2022
The study explores the transcriptomic profile of CD8+ T cells in the brains of aged and Alzheimer's disease (AD) transgenic mice, comparing them to CD8+ T cells in the blood and identifying them as ti...
KEY FINDING: Brain CD8+ T cells in both AD transgenic and aged wild-type mice exhibit a gene signature characteristic of tissue-resident memory (Trm) T cells.