Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 441-450 of 730 results
Journal of Medical Case Reports, 2019 • April 30, 2019
This case report details a 74-year-old man who developed Aspergillus terreus spondylodiscitis following an abdominal stab wound, a previously unreported occurrence. The patient's condition was charact...
KEY FINDING: Aspergillus terreus spondylodiscitis can occur following a penetrating abdominal injury, likely due to direct inoculation of the fungus.
Journal of Neuroinflammation, 2012 • February 27, 2012
This study investigated the effects of temporal IL-6 signaling blockade on macrophage activation and inflammation following spinal cord injury (SCI) in mice. The results showed that MR16-1 treatment p...
KEY FINDING: MR16-1 treatment increased the area of spared myelin and promoted nerve fiber regeneration after spinal cord injury.
PLoS ONE, 2012 • June 20, 2012
This study investigated the role of TNFa in modulating spinal plasticity and its impact on spinal learning after injury. Using a rat model of instrumental learning, the researchers explored how interm...
KEY FINDING: Intermittent stimulation increases TNFa protein expression in the spinal cord.
International Journal of Ophthalmology, 2012 • April 18, 2012
The study aimed to evaluate the efficacy of topical Natamycin, produced in China, in treating fungal keratitis using a rabbit model. Rabbits with induced keratitis were treated with Natamycin, Natacyn...
KEY FINDING: Natamycin and Natacyn groups showed significantly better ulcer scores compared to the control group on days 10, 15, and 21.
The Journal of Neuroscience, 2013 • August 7, 2013
This study investigates the role of MMP-9 in remote inflammation and motor relearning after spinal cord injury (SCI) in mice. The findings demonstrate that elevated MMP-9 in the lumbar cord early afte...
KEY FINDING: MMP-9 is upregulated in the lumbar enlargement after thoracic SCI, resulting in remote inflammation during the first week after injury in C57BL/6 mice.
PM R, 2014 • April 1, 2014
This study investigated monocyte phenotypes in acute SCI and their correlation with circulating cytokine profiles. The study identified distinct M1/M2 monocyte dominance in SCI patients, correlating w...
KEY FINDING: Patients with SCI exhibit either M1-dominant or M2-dominant circulating monocytes (MOs), which are distinct from uninjured controls.
Curr Phys Med Rehabil Reports, 2013 • September 1, 2013
The review addresses the controversy surrounding the autoimmune response following traumatic spinal cord injury (SCI), exploring whether it is primarily neuroprotective, neurotoxic, or a combination o...
KEY FINDING: B cells may mediate a harmful autoimmune response following SCI, with B cell knockout mice experiencing less reduction in motor function after SCI than wild-type mice.
Jundishapur J Microbiol, 2014 • January 1, 2014
This study investigated the prevalence, causative agents, and risk factors for urinary tract infections (UTIs) in spinal cord injury (SCI) patients. The research was conducted at rehabilitation center...
KEY FINDING: The prevalence of asymptomatic bacteriuria was 67.7%, and symptomatic urinary tract infection was 22.6% among the spinal cord injury patients studied.
Cell Medicine, 2011 • January 1, 2011
This study explored the mechanisms for functional recovery in SCI rats after intravenous transplantation of MSCs derived from human umbilical cord blood. MSC-treated rats showed a modest but significa...
KEY FINDING: MSCs transplantation resulted in modest but significant improvement in locomotor function of SCI rats.
Experimental & Molecular Medicine, 2021 • April 15, 2021
The study investigates the role of 4-1BB signaling in age-related bone loss in mice. It finds that 4-1BB and its ligand 4-1BBL accumulate in the bone marrow of aged mice. Upregulation of 4-1BB in bone...
KEY FINDING: 4-1BB is upregulated in BMSCs from aged mice, which leads to the attenuation of osteogenic differentiation potential via the p38 MAPK-Dkk1 pathway.