Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 451-460 of 730 results
Frontiers in Immunology, 2021 • May 10, 2021
The complement system plays crucial roles in CNS development, health, injury, and disease. This Research Topic gathers contributions on how complement factors interact with the nervous system, providi...
KEY FINDING: C3aR-/- mice have abnormalities in the organization and morphology of the adult neocortex, amygdala, and hippocampus, associated with motor hyperactivity and altered cognitive functions including short-term memory deficits.
Neural Regeneration Research, 2022 • January 1, 2022
Axonal regeneration after spinal cord injury is hindered by severe inflammation, the formation of a cavity of injury (COI) or arachnoiditis, and the presence of myelin. Inhibition of inflammation is a...
KEY FINDING: Severe inflammation following SCI, lasting over 16 weeks, is destructive to adjacent white matter.
J. Exp. Med, 2021 • August 2, 2021
This study used single-cell RNA sequencing to generate a detailed transcriptomic profile of cells at the spinal cord injury site. The researchers identified major cell types and their interactions dur...
KEY FINDING: The study identified distinct temporal regulation of angiogenesis, gliosis, and fibrosis by myeloid subtypes.
Infection, 2021 • June 16, 2021
The study investigated the seroprevalence of anti-SARS-CoV-2 antibodies in Austrian blood donors, finding an overall rate of 2.5%. Younger donors showed higher seroprevalence, and rates increased over...
KEY FINDING: The overall anti-SARS-CoV-2 seroprevalence among Austrian blood donors was 2.5%.
Crit Care, 2021 • June 29, 2021
This study identifies CEA as a potential biomarker for COVID-19 patients, exploring its underlying mechanism through single-cell transcriptomics. The research reveals that developing neutrophils/neutr...
KEY FINDING: CEA was identified as the only laboratory indicator with a significant difference in both univariate and multivariate analyses.
International Journal of Molecular Sciences, 2021 • July 30, 2021
This study demonstrates that distinct preceding induction by activin A, BMP-4, CHIR, and VEGF in lipid-enriched APEL medium resulted in a significant increase of hiPSC-derived platelet production using...
KEY FINDING: A modified protocol including activin A and CHIR99021 significantly increased HEC differentiation, resulting in improved MK production.
Nucleic Acids Research, 2021 • August 7, 2021
The study identifies six new ApiAP2 transcription factors associated with gametocytogenesis in Plasmodium falciparum, with PfAP2-G5 being indispensable. PfAP2-G5 acts as a repressor of the pfap2-g gen...
KEY FINDING: PfAP2-G5 suppresses the transcriptional activity of the pfap2-g gene via binding to both the upstream region and exonic gene body, preventing initiation of sexual commitment.
J Neuroinflammation, 2021 • July 11, 2021
The study investigates the potential of Schwann cell-derived exosomes (SCDEs) to promote functional recovery after spinal cord injury (SCI) in mice. SCDEs treatment increases Toll-like receptor 2 (TLR...
KEY FINDING: SCDEs treatment promotes functional recovery and induces TLR2 expression on astrocytes while decreasing CSPGs deposition post-SCI.
Stem Cells International, 2021 • August 24, 2021
This study investigates the use of umbilical cord mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite (HA) scaffolds for treating vertebral bone defects caused by spondylitis tuberculosis. T...
KEY FINDING: The study found increased bone formation at the defect site over six months, with 75-100% of the bone area showing formation. This suggests the stem cell and scaffold combination supports bone regeneration.
Clin Exp Immunol, 2021 • September 7, 2021
This review explores the proregenerative roles of Tregs in zebrafish and mammals, highlighting the FoxP3-dependent immunosuppressive function of Tregs in zebrafish as a useful model for future researc...
KEY FINDING: Zebrafish possess two FOXP3 orthologs, foxp3a and foxp3b, potentially serving a redundant role in Treg formation and activity.