Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 391-400 of 730 results
PLOS ONE, 2017 • February 7, 2017
This study aimed to define the role of nucleic acid sensors triggering innate immune response from SCI PBMC. The researchers found that SCI patients with level of injury above T-6 displayed impaired T...
KEY FINDING: SCI patients’ B-cell and plasmacytoid dendritic cells retain their functionality in response to TLR7 and TLR9 ligand stimulation as they secreted similar levels of IL6 and IFNα compared to healthy controls.
J Spine Surg, 2015 • December 1, 2015
A total of 582 patients with TB of the cervical, thoracic and lumbar spine with moderate to severe cord compression were studied. Variable degrees of neurological deficit with deformity were treated f...
KEY FINDING: Neurological improvement occurred in all patients except for 2 cases (0.3%).
Clinical Pharmacology in Drug Development, 2021 • March 1, 2021
This study reports the first clinical experience with MW189, a novel CNS-penetrant small molecule that selectively suppresses injury- and disease-induced glial proinflammatory cytokine overproduction....
KEY FINDING: MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with infusion-site reactions being the most common adverse event.
Drug Design, Development and Therapy, 2020 • December 4, 2020
This study investigates the effect of sanguinarine (SG) on chronic constriction injury (CCI)-induced neuropathic pain (NP) in rats. SG is a natural plant medicine known for its anti-inflammatory and n...
KEY FINDING: Sanguinarine (SG) treatment increased paw withdrawal mechanical threshold (PWT) and thermal withdrawal latency (TWL) in CCI rats, indicating reduced mechanical sensitivity and heat hypersensitivity.
TheScientificWorldJOURNAL, 2006 • February 17, 2006
The objective of this article was to determine the current practice on amikacin dosing and monitoring in spinal cord injury patients from spinal cord physicians and experts. This study shows that ther...
KEY FINDING: Clinical practice varies considerably across spinal units regarding amikacin administration, with some using once-daily dosing and others using divided doses.
Spinal Cord Series and Cases, 2017 • May 11, 2017
This case report describes the successful use of ceftolozane/tazobactam (C/T) to treat a febrile urinary tract infection (UTI) caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA) in a 35-...
KEY FINDING: Ceftolozane/tazobactam was effective in treating a febrile UTI caused by multidrug-resistant Pseudomonas aeruginosa in a patient with a neurogenic bladder.
Journal of Orthopaedic Surgery and Research, 2017 • March 24, 2017
This study investigates the roles of iron overload and subsequent microglia activation in the remodeling of the brain after SCI. The results indicate that after SCI, activation of IRP can lead to intr...
KEY FINDING: SCI induces intracranial iron overload, especially in the hindlimb sensory area, hippocampus, and thalamus.
Mediators of Inflammation, 2017 • May 10, 2017
This study investigates the effects of methylprednisolone (MP) on edema and aquaporin 4 (AQP4) expression in rats following spinal cord injury (SCI). The results indicate that MP, contrary to its inte...
KEY FINDING: SCI increased AQP4 expression in the spinal cord white matter, and MP diminished this increase to baseline levels.
BMJ Case Rep, 2017 • May 29, 2017
This case report describes a patient with cervical spinal cord injury and quadriparesis who developed prolonged fever. Initial treatment focused on a catheter-related bloodstream infection, but the fe...
KEY FINDING: QUAD fever should be considered in patients with high spinal cord injuries who present with fever and when other causes have been excluded.
Journal of Neuroinflammation, 2008 • June 25, 2008
This study investigates the expression of complement mRNAs and the presence of complement proteins associated with polymorphonuclear leukocytes (PMNs) after spinal cord injury (SCI). Cultured PMNs exp...
KEY FINDING: Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture. Complement protein C1q or C3 was also detected in less than 30% of cultured PMNs.