Compromised T-cell immunity in patients with spinal cord injury and its relationship with injury characteristics

This study investigates the impact of spinal cord injury (SCI) on the immune system, specifically focusing on T-cell activity in patients with chronic SCI. The researchers aimed to determine how the level and completeness of the spinal cord injury, along with autonomic dysfunction, affect the body's T-cell immune response. The study found that T-cell activity is impaired in chronic SCI patients with higher levels of injury, and the completeness of the injury and autonomic dysfunction gain prominence as factors that compromise T-cell immunity.

• 1
  Patients with incomplete SCIs had a higher skin response to candida compared to those with complete SCIs.
• 2
  Incomplete SCI patients had higher percentages of lymphocytes and CD3+CD25+ and CD3+CD69+ T cells compared to complete SCI patients.
• 3
  When patients with complete injuries were compared, the CD45+ cell percentage was found to be significantly higher in patients with injury at T6 or above.