Immunology Research

KEY FINDING: Macrophages are recruited to the regenerating limb and heart, contributing to ECM remodeling, clearance of cellular debris and senescent cells.

KEY FINDING: HMGB1 expression increases rapidly after SCI and lasts for an extended period, potentially influencing the severity and recovery process. It remains elevated even in chronic stages, warranting further investigation into its mechanisms and effects.

KEY FINDING: Infiltrating LysM(+) cells are rapidly recruited to injury sites and are associated with the collapse of distended axon terminals (DATs) caudal of injury sites.

KEY FINDING: HMGB1 is primarily located in the centromeric regions of Plasmodium falciparum chromosomes.

KEY FINDING: An acute and transient inflammation response is necessary to induce stem cell proliferation.

KEY FINDING: The combination of LPS and regulatory IL4 and IL13 signaling in macrophages and microglia produces a reparative phenotype devoid of pro-inflammatory neurotoxic features.

KEY FINDING: Seventeen kinds of immune cells showed different levels in SCI patients versus healthy controls, with seven immune cell types significantly increased after SCI.

KEY FINDING: A patient with paraplegia developed a CRE urinary tract infection and sepsis one month post-injury, requiring treatment with colistin.

KEY FINDING: A deep-seated sacral abscess can present with unusual symptoms like seizures and altered consciousness in SCI patients.

KEY FINDING: There was no correlation between microglia populations and neuron populations at the microelectrode-tissue interface.