Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 301-310 of 730 results
Journal of Neuroinflammation, 2021 • September 2, 2021
This study investigates the role of Heat shock transcription factor 1 (HSF1) in suppressing the conversion of A1 astrocytes following spinal cord injury (SCI) in rats. The results showed that HSF1 pro...
KEY FINDING: HSF1 protein levels increase in astrocytes after spinal cord injury in rats, showing colocalization with astrocytes at lesion sites.
Trials, 2021 • September 15, 2021
This pilot trial aims to assess the feasibility of using oral immunomodulation with E. coli lysate (Uro-Vaxom) to prevent UTIs in individuals with SCI during primary rehabilitation. The study will enr...
KEY FINDING: The primary objective of this pilot trial is to evaluate the feasibility of a main trial regarding the effects of oral immunomodulation.
Stem Cells International, 2021 • July 24, 2021
Implanted stem cells can differentiate into neural cells, replacing damaged cells and releasing neurotrophic factors that aid neuroprotection and axonal regeneration. Stem cells in the SCI microenviro...
KEY FINDING: Stem cells can differentiate into neural cells and produce growth factors that promote neuronal survival and axonal regrowth in the SCI microenvironment.
Neurotrauma Reports, 2022 • January 1, 2022
This study investigates the role of T and B lymphocytes in the development of neurogenic heterotopic ossification (NHO) after spinal cord injury (SCI) in a mouse model. The findings suggest that T and...
KEY FINDING: B lymphocytes increase in muscles after SCI and muscle injury, while their numbers decrease in the spleen and blood. T cell frequencies show minimal changes.
Frontiers in Immunology, 2022 • March 24, 2022
This study aimed to evaluate the expression of CMPK2 and activation of the NLRP3 inflammasome in rats with SCI and to characterize the effects of electroacupuncture on CMPK2-associated regulation of th...
KEY FINDING: Spinal cord injury significantly increased the expression levels of both NLRP3 and CMPK2 in the spinal cords of rats.
Curr Opin Pharmacol, 2022 • June 1, 2022
Infections impair neurological outcome and increase mortality after spinal cord injury (SCI). Emerging data show that pathogens more easily infect individuals with SCI because SCI disrupts neural and ...
KEY FINDING: SCI disrupts neural and humoral control of immune cells, leading to SCI-IDS.
Frontiers in Microbiology, 2022 • May 10, 2022
This study developed phage cocktails effective against E. coli strains isolated from urine of patients with spinal cord injury (SCI), which exhibit strong biofilm-forming properties, addressing the cha...
KEY FINDING: Nine phages were identified that individually decreased cell viability by >80% when added to biofilms of two E. coli strains in human urine.
Journal of Pain Research, 2022 • May 5, 2022
This study demonstrated that Z-guggulsterone significantly alleviated mechanical and thermal hyperalgesia induced by CCI in mice. The study observed that Z-guggulsterone inhibited astrocytes activatio...
KEY FINDING: Z-guggulsterone significantly reduced mechanical and thermal hyperalgesia (increased sensitivity to pain) in mice with CCI.
Clin Case Rep, 2022 • May 1, 2022
The case report describes an 84-year-old male who developed longitudinally extensive transverse myelitis (LETM) following a SARS-CoV-2 infection. The patient presented with urinary retention, lower li...
KEY FINDING: SARS-CoV-2 infection can lead to longitudinally extensive transverse myelitis (LETM), even in older adults.
Journal of Neurology, 2022 • May 24, 2022
This study analyzed T lymphocyte subpopulations in PD patients and healthy controls, finding significant differences in naïve CD8+ T cells and late-differentiated CD4+ T cells. These T-cell changes we...
KEY FINDING: PD patients exhibited decreased naïve CD8+ T cells and increased late-differentiated CD4+ T cells compared to healthy controls.