Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 191-200 of 730 results
Int. J. Mol. Sci., 2024 • February 18, 2024
This study investigates the therapeutic potential of MSC-derived exosomes in alleviating spinal cord injury (SCI) by modulating neutrophil extracellular trap (NET) formation. The research focuses on t...
KEY FINDING: Exosome treatment improved motor function recovery and reduced injury size in rats with spinal cord injuries.
bioRxiv preprint, 2024 • February 18, 2024
The study investigates the short and long-term effects of mouse serum-derived sEVs on pain modulation. sEVs from both naïve control and SNI model donor mice were found to transiently increase basal me...
KEY FINDING: Mouse serum-derived sEVs transiently increased basal mechanical thresholds in recipient mice, an effect mediated by opioid signaling.
Journal of Neuroinflammation, 2024 • February 16, 2024
This study investigates the role of cerebrospinal fluid (CSF) in the dissemination of neuropathic pain, leading to widespread pain symptoms. The key finding is that interleukin-6 (IL-6) in the CSF of ...
KEY FINDING: CCI-ION induced local pain in vibrissa pads together with widespread pain in hind paws.
Cell Communication and Signaling, 2024 • February 22, 2024
This study investigates the role of Interleukin-4 (IL-4) released from curcumin-activated olfactory ensheathing cells (aOECs) in modulating microglial polarization from the M1 to M2 phenotype, thereby...
KEY FINDING: Interleukin-4 (IL-4) plays a leading role in triggering the M1 to M2 microglial phenotype, appreciably decreasing the levels of M1 markers and elevating the levels of M2 markers.
Frontiers in Neurology, 2024 • February 21, 2024
Neuroinflammation in the context of acquired traumatic CNS injury underscores the complexity and multifaceted nature of the neuroimmune response. Recent advances in understanding the metabolic and phe...
KEY FINDING: Neuroinflammation plays a pivotal role in both the acute and chronic phases of CNS injuries, with the potential to either exacerbate damage or contribute to recovery.
PLoS ONE, 2024 • March 20, 2024
This study evaluated the therapeutic potential of maropitant in treating neuropathic pain in rats by assessing its effects on oxidative stress, endoplasmic reticulum stress, and neuroinflammation in t...
KEY FINDING: Maropitant inhibited nociception with an ID50 value of 4.1 mg/kg in a neuropathic pain model induced by chronic constriction injury (CCI).
Diseases, 2024 • February 29, 2024
This comprehensive review has elucidated the distinct features and clinical progressions of tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM), shedding light on the challenges in their...
KEY FINDING: Tuberculous meningitis (TBM) can cause seizures due to elevated cerebral metabolic rate of oxygen consumption (CMRO2) and the presence of polyunsaturated fatty acids (PUFAs), rendering the brain parenchyma vulnerable to lipid peroxidation and free radical injury.
Biomedicines, 2024 • March 8, 2024
The study synthesized MSR405, a lipophilic derivative of Radix Isatidis, and investigated its therapeutic effect on spinal cord injury (SCI) model rats. MSR405 was found to improve motor function and ...
KEY FINDING: MSR405 treatment significantly improved the motor function of SCI rats, as measured by BBB scores and footprint analysis.
Cureus, 2024 • February 27, 2024
The study presents a case of ICSA in a 49-year-old man with SCI, successfully treated with minimally invasive surgery. The approach involved spinal reconstruction using penetrating endplate screws, LL...
KEY FINDING: Minimally invasive surgery (MIS) using LLIF and PPS resulted in controlling the inflammation in ICSA patients with spinal cord injuries.
Journal of Orthopaedic Surgery and Research, 2024 • March 14, 2024
The study first analyzed the effects of SP1 silencing on biological behaviors of LPS-induced BV2 cells, including cell viability, cell apoptosis, and BV2 microglia polarization. The study continued to...
KEY FINDING: LPS treatment induced cell apoptosis and inhibited microglia polarization from M1 to M2 phenotype, accompanied by an increase of Bax protein expression and a decrease of Bcl-2 protein expression, however, these effects were relieved after SP1 silencing.