Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 951-960 of 1,773 results
Wound Rep Reg, 2022 • January 28, 2022
This study investigates the role of the skin microbiome in tail regeneration of Xenopus laevis tadpoles during the refractory period, showing that microbiome composition varies between tadpole sibship...
KEY FINDING: The tadpole skin microbiome varies significantly between sibships and is altered by raising tadpoles in the antibiotic gentamicin.
Frontiers in Endocrinology, 2022 • February 17, 2022
This study comprehensively examined and elucidated the pharmacological and physiological regulation of central melanocortin signaling in the axolotl. The study found a relatively conserved protein str...
KEY FINDING: Axolotl MC3R and MC4R can be activated by a-MSH and ACTH. Axolotl MC3R exhibited a high constitutive activity, that was significantly decreased by MRAP2
Int. J. Mol. Sci., 2022 • February 28, 2022
This review summarizes the evolving changes in apoptotic and autophagic activities in the injured nerve, dorsal root ganglia, spinal cord, and brain after nerve damage. The crosstalk or interaction of...
KEY FINDING: Upregulated autophagic activities may help myelin clearance, promote nerve regeneration, and attenuate pain behavior after nerve damage.
Neural Regeneration Research, 2022 • February 28, 2022
This study investigates the functional properties of synapses made by regenerated axons in lampreys after spinal cord injury, comparing them to synapses in unlesioned animals. The findings indicate th...
KEY FINDING: Regenerated synapses below the lesion site exhibit similar amplitude and duration of single excitatory postsynaptic potentials (EPSPs) compared to unlesioned synapses, along with similar activity-dependent depression over spike trains.
Open Biol., 2022 • February 9, 2022
This study identifies Snail (Sna) as a crucial modulator of Hippo signalling-mediated tissue growth in Drosophila development. Loss of sna inhibits, while overexpression of Sna promotes, Hippo signall...
KEY FINDING: Snail is necessary and sufficient for impaired Hippo signalling-induced cell proliferation and tissue overgrowth.
Nucleic Acids Research, 2022 • March 14, 2022
This study systematically profiled the genome-wide occupancy of eighteen Apicomplexan AP2 transcription factors to identify and characterize eight heterochromatin-associated factors (PfAP2-HFs) in Pla...
KEY FINDING: Eight heterochromatin-associated ApiAP2 transcription factors (PfAP2-HFs) were identified, showing preferential enrichment within heterochromatic regions but with differential coverage profiles.
Bioessays, 2022 • June 1, 2022
This review proposes that TRPV4 and RhoA form an environmentally sensitive signaling complex that contributes to pathological cytoskeletal alterations during neurological injury and disease. Evidence ...
KEY FINDING: TRPV4 directly interacts with RhoA, leading to bidirectional functional regulation and control of actin cytoskeletal changes.
Scientific Reports, 2022 • April 7, 2022
This study comprehensively maps the expression patterns of four individual CSPGs (Aggrecan, Versican, Neurocan, and Phosphacan) in wildtype mice and in three murine models of inherited retinal degener...
KEY FINDING: In wildtype mice, Aggrecan showed a biphasic expression pattern, Neurocan and Phosphacan expression decreased with time, while Versican expression remained broadly constant.
Frontiers in Cell and Developmental Biology, 2022 • March 1, 2022
This study systematically identified alternative splicing events in single cells from adult mouse neurogenic regions using transcriptomic data. The research highlights the prevalence of multiple isofo...
KEY FINDING: Identified 3,611 alternative splicing events from 1,908 genes in single-cell transcriptomic data of adult mouse ependymal and subependymal regions.
Stem Cell Research & Therapy, 2022 • March 7, 2022
This study investigates the roles of TLR2 and TLR4 in the proliferation and differentiation of neonatal spinal cord NPCs, finding that both are required to maintain Sox2 positive precursors but have d...
KEY FINDING: Deletion of TLR2 or TLR4 significantly reduced the number of Sox2-expressing NPCs in the neonatal mouse spinal cord, indicating a role in maintaining the neural progenitor population.