TRPV4: A trigger of pathological RhoA activation in neurological disease

TRPV4 is a cell surface channel that responds to environmental stimuli and is involved in regulating cell shape. The RhoA protein, which affects the cytoskeleton, interacts with TRPV4, impacting cellular changes during neurological issues. TRPV4 inhibition could be a targeted way to limit harmful RhoA activity in various neurological diseases.

• 1
  TRPV4 directly interacts with RhoA, leading to bidirectional functional regulation and control of actin cytoskeletal changes.
• 2
  TRPV4 can both inhibit and activate RhoA, depending on the stimulus, affecting cytoskeletal dynamics.
• 3
  Inhibition of TRPV4 in animal models of neurological injury shows promise in reducing RhoA-mediated damage.