Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 941-950 of 1,773 results
npj Regenerative Medicine, 2022 • January 1, 2022
This review summarizes the role of the Hippo pathway in zebrafish regeneration, noting that Yap1/Taz signaling often enhances regeneration through promoting cell proliferation, progenitor cell dediffer...
KEY FINDING: Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration, suggesting therapeutic potential in promoting YAP/TAZ signaling to enhance mammalian regeneration.
Frontiers in Cellular Neuroscience, 2022 • January 11, 2022
This study investigates the neuroprotective effects of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) from different donors on spinal cord injury (SCI) in mice. The findings indicate th...
KEY FINDING: The therapeutic effects of hUCMSC lines were positively correlated with their inhibitory abilities on BV2 cell proliferation rates in vitro, indicating that more potent anti-inflammatory hUCMSCs led to better outcomes.
Scientific Reports, 2022 • January 28, 2022
The study establishes a motor nerve organoid model from human pluripotent stem cells to investigate axonal degeneration and regeneration under oxidative stress conditions. The model demonstrates that ...
KEY FINDING: Motor nerve organoids derived from human pluripotent stem cells (hPSCs) can be efficiently generated and exhibit characteristics of mature motor neurons.
Protein Cell, 2022 • August 1, 2022
This study reveals that the BMP signaling pathway is deficient in the chemically defined 2i condition (N/2i), which greatly impairs the developmental potential of mESCs. Addition of BMP4 in N/2i conditi...
KEY FINDING: BMP4 activation can preserve the developmental potential and safeguard the chromosomal integrity of mESCs.
The Journal of Neuroscience, 2022 • March 23, 2022
This study investigates the role of PTEN, a tumor suppressor gene, in peripheral nerve regeneration using a mouse model with conditional PTEN deletion in facial motoneurons. The results show that PTEN...
KEY FINDING: PTEN loss induces somatic, axonal, and nerve hypertrophy and reduction in physiological whisker movement in uninjured motoneurons.
Oxidative Medicine and Cellular Longevity, 2022 • February 1, 2022
This study investigates the therapeutic effects of maltol on spinal cord injury (SCI), focusing on its antioxidative and antiapoptotic properties. The research demonstrates that maltol promotes mitoph...
KEY FINDING: Maltol administration improves locomotor function after SCI, as indicated by increased BMS scores and footprint analysis.
Cells, 2022 • February 18, 2022
This study examined the response of astrocyte subpopulations to spinal cord injury (SCI) in mice. The researchers investigated whether SCI induces changes in astrocyte subpopulation distribution and e...
KEY FINDING: Astrocyte subpopulation distribution in the spinal cord did not change to a selectively synaptogenic phenotype following mouse cervical hemisection-type SCI.
Biomedicines, 2022 • January 23, 2022
This study aimed to understand the mode of action of human platelet lysate (HPL) during skin-organoid formation and immune modulation by separating extracellular vesicles (EVs) from soluble factors. T...
KEY FINDING: Proteomics showed three major clusters of protein composition separating TSEC-EVs from HPL clustering with TFF soluble fractions and TFF-EVs clustering with TSEC soluble fractions, respectively.
PNAS, 2022 • February 24, 2022
The study characterizes the landscape of m5C mRNA modifications in Plasmodium parasites, revealing higher levels in gametocytes. It identifies NSUN2 as a major mRNA m5C methyltransferase. Knockout of ...
KEY FINDING: m5C mRNA methylation is strikingly enhanced in the transcriptomes of gametocytes in both Plasmodium yoelii and Plasmodium falciparum.
Bone Research, 2022 • January 17, 2022
The review summarizes the roles of pericytes in spinal cord injury (SCI) and bone repair, highlighting their subtypes, markers, and differentiation potential. Pericytes are crucial for vascular stabil...
KEY FINDING: Pericytes are vital to vascular stability and the regulation of vascular structure, with different subtypes having different effects on blood vessels. PDGFR-β-type pericytes differentiate into smooth muscle cells, while CD146-type pericytes are essential for pericyte recruitment and BBB development.