Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 961-970 of 1,773 results
Dev Dyn, 2022 • June 1, 2022
Axolotls are valuable models for developmental and regenerative research, possessing the unique ability to regenerate most tissues well into adulthood. The sequencing of the axolotl genome and the dev...
KEY FINDING: Axolotls exhibit scarless wound healing and have a lower incidence of cancer, making them valuable for cell plasticity studies.
Biomedicines, 2022 • March 15, 2022
This study explores the therapeutic potential of hEpi AD–MSC exosomes for spinal cord injury (SCI) in rats. Exosomes were isolated, characterized, and administered intravenously to SCI-induced rats. R...
KEY FINDING: hEpi AD–MSC exosomes improved the locomotor function of SCI-induced rats, as measured by the BBB locomotor scale.
Biomolecules, 2022 • March 12, 2022
This study identifies three L1 antagonistic mimetics—anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol—that inhibit the migration of cultured tumor cells in an L1-dependent manner. The mimetics ...
KEY FINDING: Anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol competitively inhibit antibody 324 binding to L1, suggesting they interfere with L1's function.
International Journal of Molecular Sciences, 2022 • March 15, 2022
This review highlights the potential of sovateltide, a selective ETBRs agonist, as a therapeutic candidate for neurological disorders. Preclinical and clinical studies suggest its safety and efficacy ...
KEY FINDING: Sovateltide has shown promise in preclinical studies for treating cerebral stroke, Alzheimer's disease, spinal cord injury, and neonatal hypoxic-ischemic encephalopathy by promoting neuroprotection and neuroregeneration.
Frontiers in Cell and Developmental Biology, 2022 • March 8, 2022
This review focuses on ATF3, a transcription factor that is emerging as a conserved pro-regenerative factor across vertebrates, particularly in the nervous system. ATF3 is consistently induced in neur...
KEY FINDING: ATF3 protein is highly conserved across vertebrate species, suggesting it may share similar functions in the nervous system.
Cell Death and Disease, 2022 • March 11, 2022
The study demonstrates that miR-592 plays a crucial role in neurogenesis and social interaction. Knockout of miR-592 leads to impaired motor coordination and social interaction deficits in mice. MeCP2...
KEY FINDING: miR-592 knockout in mice represses the transition from IPCs to mature neurons, leading to impaired motor coordination and reduced social interaction.
Scientific Reports, 2022 • April 8, 2022
This study investigated the miRNA profiles of human umbilical cord blood mesenchymal stem cells (CB-MSCs) during their differentiation into motor neuron-like cells using retinoic acid (RA) and sonic h...
KEY FINDING: MiR-9-5p and miR-324-5p were significantly up-regulated in cells treated with retinoic acid (RA) and sonic hedgehog (Shh), suggesting their involvement in early motor neuron differentiation. The analysis of miRNA sequencing demonstrated a significant up-regulation of miR-9-5p and miR-324-5p in Test 1 (RA + /Shh +).
Journal of Extracellular Vesicles, 2022 • March 2, 2022
This study investigates the functional role of the protein corona surrounding extracellular vesicles (EVs) derived from human placental-expanded (PLX) stromal cells. The researchers found that this co...
KEY FINDING: PLX-EVs are surrounded by a functional protein corona when enriched with permissive technology, containing immunomodulatory and proangiogenic proteins.
Cellular and Molecular Life Sciences, 2022 • April 13, 2022
Spinal cord injury induces mitochondrial dysfunction, resulting in ROS generation, loss of bioenergetics, and cell death, that together with the initial damage, induce a switch towards a glycolytic me...
KEY FINDING: Mitochondrial dysfunction is a common event in different triggers leading to cell death after SCI.
The Journal of Neuroscience, 2022 • May 18, 2022
The study demonstrates that NogoA, an NgR1 ligand, regulates commissural axon guidance in the chicken spinal cord. Live imaging shows that interfering with the Nogo/NgR1 pathway alters commissural axo...
KEY FINDING: Loss of either NgR1 or NgR3 causes commissural axons to stall in the midline area and interferes with the rostral turn of postcrossing axons in the developing chicken spinal cord.