Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 911-920 of 1,773 results
Oxidative Medicine and Cellular Longevity, 2021 • October 1, 2021
This study investigated the therapeutic potential of exosomes derived from rat bone marrow mesenchymal stem cells (MSCs) loaded with miR-494 (Exo-miR-494) for spinal cord injury (SCI) treatment. In vi...
KEY FINDING: Exosomes can be effectively loaded with miR-494 using chemical transfection, resulting in a high loading rate and stability, protecting the miRNA from degradation in the body.
Journal of Immunology Research, 2021 • September 24, 2021
This study investigates the impact of various stress conditions on the release of extracellular vesicles (EVs) by Trypanosoma cruzi trypomastigotes. The research examines how factors like temperature,...
KEY FINDING: Low temperatures (4°C) and acidic conditions (pH 5.0) increase EV release by Trypanosoma cruzi trypomastigotes.
NATURE COMMUNICATIONS, 2021 • October 14, 2021
The study addresses the divergence between embryonic development and adult regeneration in lizard tails, particularly concerning skeletal tissue patterning and dorsoventral organization. Researchers u...
KEY FINDING: Embryonic NSCs transplanted into adult ETs lose roof plate identity and are ventralized by the unchecked Hedgehog signaling of adult lizard tail environments.
Journal of Extracellular Vesicles, 2021 • September 23, 2021
This study introduces a QCM-I and AFM-based protocol for characterizing EVs by elasticity and surface markers, tailored for reproducibility and integration in existing labs. The method utilizes specif...
KEY FINDING: The study established QCM as a sensitive label-free method for characterizing clinically approved umbilical cord MSC-EVs, detecting EVs via specific EV and MSC markers.
Endocrine Connections, 2021 • October 22, 2021
This study investigates the evolutionary conservation and functional divergence of two homologous MC3Rs in the allotetraploid frog Xenopus laevis in vitro. The study clarified the interaction between ...
KEY FINDING: xlMRAP2.L/S enhances α-MSH-stimulated xlMC3Rs signaling and reduces their surface expression.
Cells, 2021 • October 7, 2021
This study systematically reviews experimental treatments for oedema following spinal cord injury (SCI). It identifies key modalities such as selective inhibition of aquaporin 4 (AQP4), modulation of ...
KEY FINDING: Selective inhibition of aquaporin 4 (AQP4), modulation of inflammation, and surgical interventions are key modalities that attenuate oedema following spinal cord injury.
Cells, 2021 • October 17, 2021
This review discusses the role of aldynoglia cells, particularly ependymocytes, tanycytes, and ependymal stem cells (EpSCs), in neuroinflammatory and neuroimmune responses following spinal cord injury...
KEY FINDING: Aldynoglia cells, including ependymocytes, tanycytes and ependymal stem cells, play a crucial role in the regeneration of spinal neural tissue after SCI.
npj Regenerative Medicine, 2021 • January 1, 2021
This study investigates the early transcriptome changes after spinal cord injury (SCI) in Xenopus laevis larvae to identify signals triggering neural stem progenitor cell (NSPC) proliferation. The ana...
KEY FINDING: mTORC1 is rapidly and transiently activated after spinal cord injury (SCI) in Xenopus laevis larvae.
Front. Cell Dev. Biol., 2021 • October 11, 2021
This study used bioinformatics analysis to identify key eRNAs involved in spinal cord injury (SCI). The analysis revealed a regulatory network of transcription factors, eRNAs, target genes, immune ce...
KEY FINDING: Identified 21 DETFs, 24 DEeRNAs, and 829 DETGs in SCI patients compared to healthy controls.
Iranian Journal of Basic Medical Sciences, 2021 • July 1, 2021
The study examined the expression of adrenomedullin (AM) and its receptors in rat dorsal root ganglion (DRG) and spinal motor (SM) neurons, finding that both neuron types express AM, CLR, RAMP2, and R...
KEY FINDING: AM increases cAMP accumulation and p-CREB levels in both DRG and SM neurons. This suggests a role for the cAMP/CREB signaling pathway in AM's effects.