Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 921-930 of 1,773 results
WIREs Mechanisms of Disease, 2021 • March 1, 2021
The spinal cord is divided into motor and somatosensory circuits. Sensory stimuli are processed by dorsal interneurons (dIs) in the dorsal spinal cord, which relay information to the brain or motor ci...
KEY FINDING: Dorsal interneuron fates are specified by mechanisms distinct from those in the ventral spinal cord.
Journal of Orthopaedic Translation, 2021 • September 28, 2021
In particular, exosomal miRNA has been shown to regulate protein expression in recipient cells and have functional role in vivo. It has been reported that treatment by exosomes in the early stage afte...
KEY FINDING: MSCs derived exosomes containing genetic materials (such as miRNA-486, miRNA-21, miRNA-133b, and miRNA-126 et al.) can be used as a cell-free treatment strategy, which have great potential to promote functional recovery, and their contents can be used as biomarkers of SCI.
Biomolecules, 2021 • November 10, 2021
The review focuses on how thrombin modulates Schwann cell pro-regenerative capacities through PAR1 after peripheral nerve injury. Besides thrombin, other proteases like FXa, FVIIa, APC, plasmin, and M...
KEY FINDING: Low levels of thrombin enhance peripheral nerve regeneration after crush injury, whereas high concentrations have detrimental effects.
Cells, 2021 • October 29, 2021
The study investigates the role of transglutaminase 2 (TG2) in astrocytes following spinal cord injury (SCI) using a mouse model with astrocyte-specific TG2 deletion (TG2-A-cKO). Deletion of TG2 in as...
KEY FINDING: Deletion of TG2 from astrocytes resulted in a significant improvement in motor function following SCI.
Frontiers in Cell and Developmental Biology, 2021 • November 19, 2021
This study investigates the role of Mauthner cells (M-cells) in post-injury startle responses following spinal cord crush in adult goldfish. The researchers examined the morphological, behavioral, and ...
KEY FINDING: M-axons can survive for at least 468 days (∼1.3 years) after spinal cord crush, maintain regrowth, and elicit putative trunk EMG responses.
Journal of Neuroinflammation, 2021 • December 1, 2021
This review provides a comprehensive overview of the inflammatory process following SCI, focusing on the timeline of cell infiltration and cytokine profiles in rodent models. Similarities and differen...
KEY FINDING: Proinflammatory cytokines TNFɑ, IL-1β, and IL-6 are key players early in the injury timeline, with significant upregulation within hours after SCI.
iScience, 2021 • December 17, 2021
This study investigates the role of the cGAS/STING pathway in peripheral nerve injury (PNI) and regeneration. The study found that the cGAS/STING pathway is upregulated in the sciatic nerve following ...
KEY FINDING: The cGAS/STING pathway is upregulated in the sciatic nerve after PNI and is dysregulated in aged rats, suggesting a role in the inflammatory response to nerve injury.
AGING, 2021 • December 17, 2021
Autophagy is an important cellular mechanism for maintaining cellular homeostasis, and its impairment correlates highly with age and age-related diseases. As a newly identified autophagy modulator, Cy...
KEY FINDING: ZTK and MTK affected lysosomal degradation, but only ZTK regulated autophagosome formation.
EBioMedicine, 2022 • January 1, 2022
This study investigates the impact of allergy-induced systemic inflammation on tendon quality using a mouse model and human health survey data. The findings demonstrate that allergic inflammation nega...
KEY FINDING: Tendons from allergic mice exhibited a significant reduction in both elastic modulus and tensile stress.
International Journal of Molecular Sciences, 2022 • January 5, 2022
The study evaluates the effectiveness of spliceosome-mediated RNA trans-splicing (SMaRT) as a targeted cancer therapy approach for epidermolysis bullosa-associated skin cancer (RDEB-SCC). The results ...
KEY FINDING: RTM44, an RNA trans-splicing molecule, can effectively target the cancer gene Ct-SLCO1B3 in RDEB-SCC cells, leading to the expression of a fusion product at the mRNA and protein level.