Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 841-850 of 1,773 results
Pain Research and Management, 2019 • April 28, 2019
The study aimed to clarify the mechanisms underlying pain reduction by PRF treatment on DRG, focusing on the levels of BDNF, PI3K, and p-ERK in the spinal cord of rats with spared nerve injury (SNI). ...
KEY FINDING: SNI induced a long-lasting increase in microglia hyperactivity and BDNF, PI3K, and p-ERK upregulation in the spinal cord and resulted in pain sensitization.
Physiol Rep, 2019 • July 1, 2019
This study investigated the interactive effects of myostatin (Mstn) and AdipoRon on hepatic gene expression and function in a mouse hepatocyte line. Mstn increased fatty acid accumulation and desensit...
KEY FINDING: Myostatin (Mstn) increases fatty acid accumulation and desensitizes cellular responses to insulin in hepatocytes.
Annals of Rehabilitation Medicine, 2019 • July 1, 2019
This study investigated the potential of miRNA-21 and miRNA-223 as indicators of the severity and acute phase of spinal cord injury (SCI) using a balloon-compression model in rats. The results showed ...
KEY FINDING: Significant differences in miRNA-21 expression levels were observed between the experimental groups at 1, 3, and 7 days post-injury, suggesting that miRNA-21 expression levels might serve as an indicator of the severity of SCI.
Physiol Rep, 2019 • August 5, 2019
This study examined the effects of spinal cord injury (SCI) on oxidative stress and antioxidant defenses in human skeletal muscle over the first year post-injury. Muscle biopsies were analyzed at 1, 3...
KEY FINDING: Increased protein content of NADPH oxidase 2, xanthine oxidase, and pro-caspase-3 was observed at 1 and 3 months after spinal cord injury compared to able-bodied controls, suggesting increased ROS production and apoptotic signaling.
Enzyme Research, 2012 • June 16, 2012
This study introduces a new method for detecting activated caspases in whole-mounted brain preparations using FLICA reagents, demonstrating its effectiveness in identifying apoptotic neurons in the la...
KEY FINDING: FLICA reagents can effectively detect specific activated caspases in identified neurons within the whole-mounted lamprey brain.
PLoS ONE, 2012 • November 8, 2012
This study explored the impact of the ACTN3 R577X polymorphism on single muscle fiber contractile properties in individuals with spinal cord injury (SCI). The SCI condition provided a standardized env...
KEY FINDING: Absence of a-actinin-3 (XX genotype) resulted in a limitation in the shift of muscle composition towards type IIx fibers and preservation of type I fibers in response to long-term muscle disuse.
PLoS ONE, 2012 • December 1, 2012
This study investigates the use of photomechanical waves (PMWs) to deliver small interfering RNAs (siRNAs) targeting intermediate filament (IF) proteins, such as GFAP and vimentin, to SCI model rats. ...
KEY FINDING: PMW-mediated delivery of siRNAs targeting GFAP and vimentin resulted in significant improvement in locomotive function from five days post-injury.
Mediators of Inflammation, 2013 • February 2, 2013
Individuals with spinal cord lesions have a higher risk for obesity and, consequently, low-grade chronic inflammation due to the accumulation of visceral fat and the subsequent increased production of...
KEY FINDING: Spinal cord injury is associated with increased serum concentrations of C-reactive protein, interleukin 6 (IL-6), and endothelin-1, suggesting a state of chronic inflammation independent of obesity.
PLoS ONE, 2013 • May 24, 2013
The study investigated chronic progressive compression of the cervical spinal cord in twy/twy mice, finding neuronal loss and increased CD11b-positive cells at the compression site. The research revea...
KEY FINDING: The number of CD11b positive microglia/macrophages increased with the severity of spinal cord compression.
J Korean Neurosurg Soc, 2013 • June 1, 2013
This study investigated the alterations in the expression of key regulators of neuronal development, survival, and death following SCI in mice. The findings revealed a significant increase in BDNF exp...
KEY FINDING: BDNF expression was significantly elevated in the SCI group compared to the control group at 2 weeks after SCI.