Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 851-860 of 1,773 results
Int. J. Mol. Sci., 2022 • November 2, 2022
The study investigates the gene activation profile of the stressed holothurian CNS using RNA sequencing to compare transected and enzyme-dissected RNC explants with cultured explants. The research ide...
KEY FINDING: Several stress-associated genes, including heat-shock proteins and ubiquitin-related pathways, are differentially expressed in the holothurian CNS following transection and enzyme dissection.
Crit Care Med, 2014 • June 1, 2014
This study compares the dynamic systemic inflammatory responses of TSCI vs. non-SCI patients, suggesting a key role for IP-10 in driving systemic IL-10 and morbidity. The systemic inflammatory respons...
KEY FINDING: Circulating IL-10 was significantly elevated in thoraco-cervical TSCI vs. non-SCI, whereas IL-1β, sIL-2Rα, IL-4, IL-5, IL-7, IL-13, IL-17, MIP-1α and -1β, GM-CSF, and IFN-γ were significantly reduced in TSCI vs. non-SCI.
Neural Regeneration Research, 2014 • February 1, 2014
The Olig family, including Olig1, Olig2, and Olig3, are critical transcription factors involved in neural cell subtype selection during central nervous system development. These factors play significa...
KEY FINDING: Olig1 and Olig2 are essential for oligodendrocyte differentiation and maturation, with Olig2 acting as an early-stage factor and Olig1 playing a critical role in later stages of myelin formation.
Acta Neurochirurgica, 2021 • April 5, 2021
Herein, we found that BMSC-Shh-Exos were able to effectively protect rats against SCI-associated pathology by promoting neuronal functional recovery, survival, and by inhibiting the excessive activati...
KEY FINDING: Both BMSC-Exo and BMSC-Shh-Exo preparations significantly increased Shh expression in the spinal cord of SCI model rats and improved BBB scores in these treated animals.
PNAS, 2021 • April 7, 2021
This study presents the chromosome-level assembly of the giant axolotl genome, providing a valuable resource for understanding genome organization, evolution, and gene regulation in this important mod...
KEY FINDING: The chromosome-scale assembly of the 32 Gb axolotl genome was achieved using Hi-C contact data.
Molecular Neurobiology, 2021 • April 15, 2021
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. Conditional mouse mutants have revealed the functional significance of neuronal and glia...
KEY FINDING: FGFs play a crucial role in the regeneration and repair of the nervous system, with FGFR1 and FGFR2 stimulation inducing neural tissue regeneration in planarians and vertebrate embryos.
Neurotherapeutics, 2021 • April 15, 2021
The study investigates the potential of a novel antisense oligonucleotide (NVP-13) to recondition the neurogenic niche in adult non-human primates by attenuating TGFβ signaling. NVP-13 effectively dow...
KEY FINDING: NVP-13 significantly downregulated TGFβ-RII mRNA and protein expression in vitro in human neural precursor cells.
Front. Cell Dev. Biol., 2021 • April 1, 2021
This study investigates the changes in gene expressions and DNA methylation during TSC derivation from NF, NT, and SNT blastocysts, identifying a set of 75 TFs whose transcription profiles can infer t...
KEY FINDING: Seventy-five transcription factors (TFs) are continuously upregulated during NF TSC derivation, and their transcription profiles can infer the time course of NF, but not NT, TSC derivation.
Molecular Therapy, 2021 • August 1, 2021
This study demonstrates that Gsx1 expression increases NSPCs and the generation of specific interneuron subtypes, including vGlut2+ and ChAT+ interneurons, and 5-HT neuronal activity, while reducing i...
KEY FINDING: Gsx1 expression increases the number of NSPCs in a mouse model of lateral hemisection SCI during the acute stage.
eLife, 2021 • May 14, 2021
This study investigates the mechanisms underlying spinal cord regeneration in axolotls, focusing on the spatiotemporal pattern of cell proliferation. It demonstrates that the regenerative response is ...
KEY FINDING: Spinal cord regeneration is consistent with a signal that recruits ependymal cells during approximately 85 hours after amputation within approximately 830 μm of the injury.