Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 831-840 of 1,773 results
Molecular Pain, 2018 • November 12, 2018
This study used RNA-seq to identify gene expression changes in the spinal cord of nerve-injured rats after repetitive conventional spinal cord stimulation (SCS) treatment. The RNA-seq data suggest fur...
KEY FINDING: Repetitive SCS further increases many existing upregulated immune responses in chronic constrictive injury rats, including transcription of cell surface receptors and activation of non-neuronal cells.
J Transl Med, 2018 • December 6, 2018
This study presents a comprehensive landscape of the gut microbiota in adult male patients with traumatic complete SCI and documents their neurogenic bowel management. We found a difference in faecal ...
KEY FINDING: The diversity of the gut microbiota in the SCI group was reduced.
MOLECULAR MEDICINE REPORTS, 2019 • January 14, 2019
This study investigates the role of miR-124 in spinal cord injury (SCI) in rats. The findings suggest that SCI induces dysregulation of miRNA expression, and miR-124 is significantly downregulated. Ov...
KEY FINDING: SCI induces dysregulation of miRNA expression, with miR-124 being significantly downregulated in spinal cord tissues.
MOLECULAR MEDICINE REPORTS, 2019 • January 1, 2019
The study aimed to identify critical genes and mechanisms involved in spinal cord injury (SCI) using gene expression profiles from trkB.T1 knockout mice. Differentially expressed genes (DEGs) were scr...
KEY FINDING: A total of 664 DEGs in the sham group and SCI groups at days 1, 3, and 7 following injury were identified in trkB.T1 KO mice.
Neural Plasticity, 2019 • February 18, 2019
This study investigates the role of microRNA-219 (miR-219) in modulating oligodendrocyte precursor cell (OPC) proliferation and differentiation following contusion spinal cord injury (SCI) in rats. Th...
KEY FINDING: SCI downregulates miR-219 expression at the lesion center of the injured spinal cord tissues in the acute and sub-acute SCI phases, with the lowest level of miR-219 expression occurring on day 7 after injury.
Sci Transl Med, 2019 • April 10, 2019
This study investigates the impact of environmental enrichment (EE) on promoting axon regeneration after spinal cord injury (SCI) in rodents. The researchers found that EE enhances the regenerative po...
KEY FINDING: Environmental enrichment (EE) enhances the regenerative potential of DRG neurons in mice, leading to increased neurite outgrowth and axonal regeneration after SCI.
Journal of Neuroinflammation, 2019 • April 8, 2019
This study investigates how macrophage migration inhibitory factor (MIF) influences the production of prostaglandin E2 (PGE2) in astrocytes after spinal cord injury (SCI). The results demonstrate that...
KEY FINDING: MIF and COX2 protein levels increased synchronously after spinal cord injury in rats. Blocking MIF reduced COX2 and mPGES-1 expression, leading to decreased PGE2 production.
Neural Plasticity, 2019 • March 11, 2019
This study investigates a combination therapy of AAV-NT3 gene therapy and exercise to reduce muscle spasms after spinal cord injury in rats. The results indicate that AAV-NT3 gene therapy, exercise, a...
KEY FINDING: AAV-NT3 gene therapy, exercise, and combination therapy all reduced spasm frequency at 6 weeks after spinal cord injury.
Frontiers in Neuroscience, 2019 • April 16, 2019
This study investigates the therapeutic potential of exosomes derived from pericytes in treating spinal cord injury (SCI) in mice. The researchers transplanted pericyte exosomes into mice with SCI to ...
KEY FINDING: Pericyte-derived exosomes improve motor function recovery in mice after SCI, as measured by Basso Mouse Scale (BMS) scores.
FEBS Open Bio, 2019 • May 2, 2019
This study investigates the role of TCTN2 long non-coding RNA on apoptosis and autophagy in SCI. The data suggest that TCTN2 enhances autophagy by targeting the miR-216b–Beclin-1 pathway, thereby amel...
KEY FINDING: TCTN2 expression is decreased in spinal cord tissues of rats with SCI and in oxygen–glucose deprivation (OGD)-induced hypoxic SY-SH-5Y cells, while miR-216b is up-regulated in these conditions.