Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 811-820 of 1,773 results
J. Cell. Mol. Med., 2018 • January 1, 2018
This review discusses the therapeutic potential and pitfalls of FGFs in treating spinal cord injuries (SCI). FGFs have shown promise in preclinical studies, promoting functional recovery through vario...
KEY FINDING: aFGF, in conjunction with a peripheral nerve graft, was proven to have a beneficial effect in the reparation of complete thoracic spinal cord transection model in rodent.
Pain, 2018 • February 1, 2018
This study demonstrates that voluntary exercise prior to I/R injury blocks the increase in muscle IL1β and subsequent pain-related behaviors, suggesting a protective effect against ischemic myalgia. T...
KEY FINDING: Voluntary exercise prior to ischemia/reperfusion injury (I/R) prevents injury-induced muscle IL1β upregulation and subsequent pain-related behaviors.
BioMed Research International, 2017 • November 19, 2017
This study investigates the apoptotic process in lamprey descending neurons after spinal cord injury (SCI), focusing on caspase activation and the involvement of the intrinsic apoptotic pathway. The r...
KEY FINDING: A significant correlation was found between the level of activated caspases (cell death markers) in identifiable neurons and their known regenerative ability after spinal cord injury in lampreys.
Physiol Rep, 2018 • January 1, 2018
This study elucidates the mechanisms by which nandrolone stimulates the differentiation of myogenic lineage cells, focusing on the roles of MyoD and Numb. The research demonstrates that androgens stim...
KEY FINDING: Nandrolone increases both MyoD mRNA and protein expression in C2C12 myoblasts, indicating an upregulation of MyoD production.
Medicine, 2018 • March 1, 2018
The study examined the ability of EPO to limit astrogliosis after modeled SCI in vitro. EPO applied up to 8 hours after injury regulated the expression of axonal growth inhibiting molecules, cytoskele...
KEY FINDING: EPO treatment up to 8 hours after injury reduced the expression of axonal growth inhibiting molecules like GFAP, vimentin and CSPG.
J South Med Univ, 2018 • February 1, 2018
This study compared the clinical efficacy of intramedullary and extramedullary decompression with lavage therapy versus extramedullary decompression alone for chronic cervical spinal cord injury. The ...
KEY FINDING: Patients undergoing intramedullary and extramedullary decompression (Group B) showed significantly higher JOA scores and improvement rates compared to those undergoing extramedullary decompression alone (Group A).
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018 • January 23, 2018
The study demonstrates that electro-acupuncture (EA) can alleviate neuropathic pain in a rat model of chronic constrictive injury (CCI). EA treatment reduces mechanical allodynia and thermal hyperalge...
KEY FINDING: EA treatment significantly increased mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) values, indicating reduced hyperalgesia and allodynia in CCI rats.
Ann Diagn Pathol, 2018 • October 1, 2018
This study investigates the role of miR-155 in spinal cord paralysis following aortic cross-clamping (ACC) in mice. The findings indicate that miR-155 contributes to gray matter edema and paralysis by...
KEY FINDING: Increased miR-155 expression in neurons and endothelial cells of the spinal cord is associated with paralysis in a mouse model of aortic cross-clamping (ACC).
JOURNAL OF NEUROTRAUMA, 2019 • March 15, 2019
This study investigates the role of bone marrow-derived monocytes in the inflammatory microenvironment after thoracic spinal cord injury (SCI). The research focuses on the infiltration of peripheral m...
KEY FINDING: Macrophages are recruited to both the epicenter and lumbar cord after thoracic SCI, and they persist for at least seven days.
INTERNATIONAL JOURNAL OF MOlecular medicine, 2018 • July 12, 2018
This study investigated the effect of ultrashortwave (USW) radiation on spinal cord injury (SCI) by examining its impact on the MK2-mediated inflammatory response. The findings suggest that USW radiat...
KEY FINDING: MK2 and TNF‑α/IL‑1β were found to be elevated in patients with SCI and in H2O2‑treated C8‑D1A cells, indicating their involvement in the inflammatory response following SCI.