Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 801-810 of 1,773 results
Eur J Appl Physiol, 2010 • April 3, 2010
This study compared oxidative stress levels between individuals with SCI and able-bodied subjects and assessed the impact of FES exercise on oxidative stress in SCI patients. The results showed no sig...
KEY FINDING: Baseline levels of oxidative stress and antioxidative capacity were similar between individuals with SCI and able-bodied subjects, suggesting a preserved (anti)oxidative status in SCI under basal conditions.
BMC Neuroscience, 2010 • July 22, 2010
This study investigated the effects of cyclic tensile stresses on cultured rat spinal cord cells using microarray analysis to identify changes in gene expression related to cell death. The results sho...
KEY FINDING: Cyclic tensile stress reduces the viability of cultured spinal cord cells in a dose- and time-dependent manner.
Eur Spine J, 2012 • September 21, 2011
This study used twy/twy mice as a model for human cervical compressive myelopathy to investigate cellular and molecular changes in the spinal cord under chronic compression. The researchers found a si...
KEY FINDING: Apoptosis of oligodendrocytes in the compressed area of the spinal cord is correlated with the magnitude of cord compression.
Behav Neurosci, 2011 • December 1, 2011
Estrous cycle disruption after SCI in female rats is a common phenomenon, and this study investigates whether it's due to the injury itself or the stress of surgery. The study found that both the spin...
KEY FINDING: Estrous cyclicality was disrupted in approximately 76%, 46%, and 50% of the rats after HX, EMG, and dye injection surgeries, respectively.
Biochemistry and Biophysics Reports, 2017 • January 17, 2017
This study investigates the effects of myostatin and an ALK4/5/7 inhibitor (SB431542) on miRNA expression in differentiating C2C12 myoblasts to understand the regulation of muscle-specific and highly ...
KEY FINDING: Myostatin (1 µg/ml) reduced the expression of miR-1 and miR-133a at 1 day post-differentiation induction but not at 3 days.
Spinal Cord, 2017 • December 1, 2017
This study aimed to determine clinical factors associated with plasma C-reactive protein (CRP) in persons with chronic spinal cord injury (SCI). In multivariable models, factors associated with a high...
KEY FINDING: Greater BMI was associated with higher CRP levels, even when accounting for body fat distribution.
BMC Pulmonary Medicine, 2017 • August 8, 2017
This study investigated the relationship between systemic inflammation and pulmonary function in individuals with chronic spinal cord injury (SCI). The results showed that higher levels of inflammator...
KEY FINDING: Plasma CRP and IL-6 were inversely associated with FEV1 and FVC in individuals with chronic SCI.
MOLECULAR MEDICINE REPORTS, 2017 • July 12, 2017
The study developed a novel method for isolating and purifying Schwann cells (SCs) from mature Rhesus monkey nerves using in vitro pre-degeneration. The method involves pre-degeneration of nerve expla...
KEY FINDING: In vitro pre-degeneration in a modified SC culture medium (SCCM) increased SC purity and yield from monkey peroneal nerves.
Nature Communications, 2017 • August 7, 2017
This study investigates how distal axon injury remodels synapses contacting injured neurons using a microfluidic approach to compartmentalize cultured neurons. The research demonstrates that axotomize...
KEY FINDING: Axotomy causes retrograde dendritic spine loss at directly injured pyramidal neurons followed by retrograde presynaptic hyper-excitability.
Scientific Reports, 2017 • September 20, 2017
The study demonstrates that skeletal muscle fibers release exosomes, extending previous research on exosomes from myoblasts and myotubes. These exosomes contain microRNAs and can be taken up by recipi...
KEY FINDING: Skeletal muscle fibers release exosomes containing proteins and miRNAs.