Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 821-830 of 1,773 results
Spinal Cord, 2018 • November 1, 2018
This report explores the relationship between circulating TG and HDL-C concentrations, and more specifically, the serum TG concentrations at which serum HDL-C equals 40 mg/dl in SCI cohorts that are a...
KEY FINDING: The serum TG concentration that intersects with a serum HDL-C of 40 mg/dl is lower in persons with SCI than in the general population.
Front. Neural Circuits, 2018 • July 25, 2018
This study demonstrates the utility of HiRet lentivirus as a tool for mapping neuronal circuitry within the brain and spinal cord, showing its ability to retrogradely label supraspinal and propriospin...
KEY FINDING: HiRet lentivirus allows efficient retrograde labeling of supraspinal and propriospinal circuits innervating motor neuron pools in the spinal cord.
International Journal of Molecular Sciences, 2023 • September 8, 2023
Exosomes, as key secretomes, have emerged as pivotal players in understanding and potentially treating SCI. This manuscript explored their multifaceted roles, from serving as transporters that can pas...
KEY FINDING: Exosomes and exosomal miRNAs enhance recovery from SCI by attenuating neuronal cell death. MSC exosomes have been shown to increase Bcl-2 expression and decrease Bax levels after systemic administration in an SCI mouse or rat model.
Neural Regeneration Research, 2018 • October 1, 2018
Depression is a significant long-term complication of traumatic brain injury (TBI) that can impair cognitive function and overall quality of life. The underlying cause of this increased depression ris...
KEY FINDING: TBI-induced inflammation, characterized by elevated cytokines, is a potential mechanism for post-TBI depression.
Journal of Neuroinflammation, 2018 • September 6, 2018
This study investigated the role of macrophage migration inhibitory factor (MIF) in the production of chemokine (C-C motif) ligand 5 (CCL5) in astrocytes following rat spinal cord injury. The results ...
KEY FINDING: CCL5 protein levels were increased in astrocytes of rat injured spinal cord, in parallel with the expression of MIF.
Biotechnol Bioeng, 2019 • January 1, 2019
This study investigated the ability of noggin and PDGF, individually or in combination, to enhance myelination of regenerating axons after spinal cord injury (SCI). Lentiviral vectors encoding noggin ...
KEY FINDING: The combination of noggin + PDGF enhanced total myelination of regenerating axons relative to either factor alone.
Neural Regeneration Research, 2018 • November 1, 2018
This study investigated the relationship between GFAP/S100B markers post-SCI and the global histone H4 acetylation levels. Results indicate global histone H4 acetylation levels exhibit a complex patte...
KEY FINDING: GFAP, but not S100B, was associated with global histone H4 acetylation levels after SCI.
Physiol Rep, 2018 • September 1, 2018
This study investigates the effects of myostatin on insulin action and glucose uptake in C2C12 muscle cells. Myostatin, known for its role in inhibiting muscle growth, is shown to impair insulin-stimu...
KEY FINDING: Myostatin significantly reduced basal and insulin-induced IRS-1 tyrosine phosphorylation, expression and activation of PI3K, associated with diminished AKT phosphorylation and elevated GSK3b phosphorylation.
Scientific Reports, 2018 • October 5, 2018
This study explored methods to enhance the recovery of cells expressing OEC marker p75NTR from rat mucosa. Key bioprocessing fundamentals were identified that will underpin future development of OEC-b...
KEY FINDING: A 24-hour differential adhesion step significantly increased the expression of p75NTR, an OEC marker, to 73 ± 5% and 46 ± 18% on PDL and laminin matrices, respectively.
JOURNAL OF NEUROTRAUMA, 2019 • June 15, 2019
This study investigates hyaluronic acid (HA) levels in the amniotic fluid (AF) of fetal rats with myelomeningocele (MMC). It compares HA concentrations in MMC-AF to normal control AF (Norm-AF) at diff...
KEY FINDING: No significant difference in HA concentration was observed between MMC-AF and Norm-AF at E18 and E20.