Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 691-700 of 1,773 results
Int. J. Mol. Sci., 2022 • October 4, 2022
This study evaluated the therapeutic potential of a selective calpain inhibitor (PD150606) in combination with methylprednisolone sodium succinate (MPSS) in a dog SCI model. The findings revealed that...
KEY FINDING: The combined administration of MPSS+PD150606 demonstrated considerably lower neuronal loss and microglial cell infiltration than the other groups, with a significant improvement in the locomotor score.
Mediators of Inflammation, 2022 • September 30, 2022
The study investigates the effects of LPA on spinal cord neurons, particularly concerning cytotoxicity, apoptosis, DNA damage, and oxidative stress, using an in vitro model. It finds that LPA (18:1) n...
KEY FINDING: LPA (18:1) treatment decreases cell viability and increases LDH release in spinal cord neurons, indicating cytotoxicity.
Frontiers in Aging Neuroscience, 2022 • October 19, 2022
The authors found that the NLRP3 inflammasome plays an important role in the treatment of some diseases by electroacupuncture. The main mechanism is that electroacupuncture reduces the inflammatory resp...
KEY FINDING: Electroacupuncture can alleviate diseases by targeting the NLRP3 inflammasome.
Translational Neurodegeneration, 2022 • December 2, 2022
This review focuses on recent research progress on the pathological roles of EVs released from CNS cells in the pathogenesis of NDs. It summarizes findings that identify CNS-derived EV cargos as poten...
KEY FINDING: EVs play a significant role in the pathogenesis of various neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease.
Int. J. Mol. Sci., 2022 • December 13, 2022
The study investigated the effects of transplanting human ADC-modified murine neural precursor cells (hADC-mNPCs) into mice with spinal cord injury (SCI). hADC-mNPC transplantation resulted in improve...
KEY FINDING: Transplantation of hADC-mNPCs improved neurological outcomes, induced oligodendrocyte differentiation and remyelination, increased neural lineage differentiation, and decreased glial scar formation.
Int. J. Mol. Sci., 2022 • December 14, 2022
The study validates that burn injury results in sciatic nerve demyelination and that Schwann cell dedifferentiation increases the expression of the immature marker p75 and reduces that of the maturate...
KEY FINDING: Spinal irisin gene delivery attenuates burn injury-induced sciatic nerve demyelination and reduction of neuromuscular junction innervation.
eLife, 2022 • December 29, 2022
This review explores the connection between inflammatory bone resorption and cardiovascular disease, highlighting epidemiological evidence linking conditions like osteoporosis and spinal cord injury t...
KEY FINDING: Chronic inflammatory conditions like post-menopausal osteoporosis, spinal cord injury, rheumatoid arthritis, and osteoarthritis are associated with an increased risk of cardiovascular disease.
Frontiers in Neuroscience, 2022 • December 15, 2022
This study investigates the role of rno-circRNA-013017 in traumatic spinal cord injury (SCI) in rats. The researchers hypothesized that rno-circRNA-013017 could inhibit apoptosis and axonal degenerati...
KEY FINDING: Overexpression of rno-circRNA-013017 reduces neuron apoptosis after SCI.
Neural Regeneration Research, 2015 • July 1, 2015
Mitochondria play an essential role in cell signaling, differentiation, and survival, and their dysfunction is linked to diverse human diseases, including neurodegenerative diseases and central nervou...
KEY FINDING: Nuclear-encoded miRNAs can be found in mitochondria and can directly regulate mitochondrial proteins, such as miR-181c targeting cytochrome c oxidase subunit 1 (COX1).
Translational Psychiatry, 2023 • January 6, 2023
This study investigated the role of polygenic risk scores (PRS) for PTSD, major depressive disorder (MDD), and neuroticism (NEU) in predicting the development of PTSD following mild traumatic brain in...
KEY FINDING: The PTSD-PRS was significantly associated with an increased risk of PTSD at 6 months post-mTBI.