Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 681-690 of 1,773 results
Oxidative Medicine and Cellular Longevity, 2021 • February 27, 2021
Spinal cord injury (SCI) results in an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, leading to oxidative stress. Dietary advice and supplements, particularly th...
KEY FINDING: Curcumin, ginseng, and green tea have potential for SCI management, but SCI individuals often have low antioxidant vitamin levels.
Frontiers in Medicine, 2021 • March 4, 2021
The study investigates the role of ZBTB20 in itch sensation using PN-ZB20KO mice and gene silencing techniques. It found that ZBTB20 is involved in both histamine- and non-histamine-dependent itch. ZB...
KEY FINDING: Histamine-dependent and non-histamine-dependent itch behaviors were significantly diminished in PN-ZB20KO mice.
Frontiers in Cell and Developmental Biology, 2021 • March 25, 2021
This study investigates the effects of chondroitinase ABC (ChABC) on axon regeneration and retrograde apoptosis signaling in lampreys after spinal cord injury (SCI). The researchers found that ChABC t...
KEY FINDING: ChABC treatment reduces the distance between axon tips and the injury site early after spinal cord injury, suggesting it inhibits axon retraction or promotes early regrowth.
Molecular Pain, 2021 • March 9, 2021
The study examined whole blood gene expression in individuals with chronic SCI compared to able-bodied individuals, focusing on differences based on pain status and pain type. Results showed distinct ...
KEY FINDING: Participants with SCI who reported pain had 468 differentially expressed (DE) genes compared to able-bodied (AB) individuals, while those without pain had 564 DE genes.
J. Clin. Med., 2021 • April 9, 2021
This systematic review aimed to assess the composition of the gut microbiota in patients with SCI or MS compared to healthy controls, considering the potential roles of neurogenic bowel function, diet...
KEY FINDING: The review found that alpha diversity in chronic SCI patients might be lower compared to healthy controls, while alpha diversity in MS patients might be similar or lower.
PLoS ONE, 2021 • May 6, 2021
This study investigated the role of the CHRFAM7AΔ2bp variant in inflammation following spinal cord injury (SCI) in 45 patients, stratified by injury severity. Results indicated that the Δ2bp variant i...
KEY FINDING: In severe SCI patients, carriers of the Δ2bp variant showed higher levels of circulating inflammatory mediators compared to non-carriers.
Neural Plasticity, 2021 • April 19, 2021
The study investigates the role of the Wnt/β-catenin pathway in neuropathic pain (NP) induced by chronic compression of the dorsal root ganglion (DRG). The researchers used a rat model to mimic lumbar...
KEY FINDING: Chronic compression of the DRG leads to changes in the expression of multiple Wnt pathway-related genes and rapid activation of the Wnt/β-catenin pathway in the DRG and spinal cord.
Cureus, 2021 • April 27, 2021
This article reviews the current literature on neurogenic heterotopic ossification (NHO), a condition characterized by pathological bone formation in soft tissues following spinal cord or brain injury...
KEY FINDING: NHO prevalence in SCI patients ranges from 10% to 53%, with lower rates in pediatric patients.
International Journal of Molecular Sciences, 2021 • May 5, 2021
Botulinum toxin has evolved from a potent poison to a valuable therapeutic agent, particularly for managing spasticity. Its application has expanded beyond its initial use in treating strabismus to va...
KEY FINDING: Botulinum toxin's mechanism involves cleaving SNARE proteins, thus blocking acetylcholine release and causing muscle relaxation.
Journal of Neuroinflammation, 2022 • January 1, 2022
In summary, multiple hypotheses have been proposed for the pathogenesis of AD, one of the most complicated and progressive neurodegenerative disease, and among them, mitochondrial dysfunction has emer...
KEY FINDING: mtDNA abnormality triggers mitochondrial dysfunction, causing inflammatory responses and microglial activation and ultimately leading to irreversible neuronal death and loss of glial function.