Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 701-710 of 1,773 results
Frontiers in Pharmacology, 2023 • January 10, 2023
This study investigates the therapeutic potential of iPSCs-Exo in treating spinal cord injury (SCI) in mice, focusing on the role of miR-199b-5p in modulating macrophage polarization and promoting neu...
KEY FINDING: iPSCs-Exo improves motor function in SCI mice and reduces the cavity volume in the injured spinal cord.
bioRxiv preprint, 2023 • January 7, 2023
We investigated the role of genetics, age and sex on AIHH-induced respiratory motor plasticity of both cortical (presumably volitional) diaphragm MEPs and brainstem automatic (P0.1) neural pathways in...
KEY FINDING: AIHH-induced changes in diaphragm MEP amplitudes were lower in individuals heterozygous for APOE4 (i.e., APOE3/4) allele versus other APOE genotypes (p=0.048).
npj Parkinson’s Disease, 2023 • January 1, 2023
This study investigates the neuroprotective effects of irisin, a myokine, in Parkinson's disease (PD) models. It demonstrates that exercise increases serum irisin levels in PD patients, correlating wi...
KEY FINDING: Regular exercise increased serum irisin levels in PD patients, which correlated positively with improved balance function.
Frontiers in Molecular Neuroscience, 2023 • February 2, 2023
This review discusses the role of microRNAs (miRNAs) in spinal cord injury (SCI), emphasizing their involvement in secondary injury mechanisms like neuroinflammation, apoptosis, and oxidative stress. ...
KEY FINDING: miRNAs regulate the expression of proteins altered after SCI by up-regulating or down-regulating target genes, influencing processes like inflammatory response, angiogenesis, and axon regeneration.
Cells, 2023 • February 14, 2023
This review analyzes experimental attempts to transform astrocytes into neurons (AtN) in adult animals, a strategy for CNS repair. The paper distinguishes between direct cell conversion and direct cel...
KEY FINDING: Direct cell conversion (1-2 TFs) and direct cell reprogramming (≥3 TFs or multifactor formulas) are proposed as distinct approaches to AtN, influencing the extent of epigenetic modification.
International Journal of Medical Sciences, 2023 • January 31, 2023
The study investigates the role of Numb and Notch signaling in denervation atrophy of skeletal muscle in mice, using nandrolone treatment and conditional knockout models. Results showed that nandrolon...
KEY FINDING: Nandrolone treatment increased Numb expression and reduced Notch signaling in denervated muscle.
Cell & Bioscience, 2023 • April 3, 2023
This study demonstrates that exosomes derived from vascular endothelial cells improve functional recovery and augment microglia/macrophages M2 polarization in vivo and in vitro. USP13 was highly upreg...
KEY FINDING: Exosomes derived from microvascular endothelial cells promote motor rehabilitation and M2 polarization of microglia/macrophages after SCI.
Mediators of Inflammation, 2023 • March 10, 2023
This study investigates the mechanism by which SET8 regulates the Keap1/Nrf2/ARE signaling pathway to influence astrocyte autophagy and promote motor function recovery after spinal cord injury (SCI) i...
KEY FINDING: Overexpression of SET8 upregulates H4K20me1 enrichment in Keap1, inhibiting Keap1 expression and activating the Nrf2-ARE signaling pathway.
Molecular Pain, 2023 • January 1, 2023
This study investigates the mechanisms underlying dynamic allodynia, a type of neuropathic pain, in a spared nerve injury (SNI) mouse model. The findings demonstrate that SNI-induced dynamic allodynia...
KEY FINDING: Downregulation of neuronal membrane KCC2 (mKCC2) in the spinal dorsal horn of SNI mice is closely associated with SNI-induced dynamic allodynia.
Sci. Adv., 2025 • April 2, 2025
This study engineered mesenchymal stem cell-derived extracellular vesicles (EVs) to enhance their therapeutic efficacy for spinal cord injury (SCI) treatment. The EVs were reinforced with pro-angiogen...
KEY FINDING: The study successfully created a hydrogel that releases EVs in response to ROS, allowing for on-demand regulation of SCI treatment.