Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 591-600 of 1,773 results
Cell Death Discovery, 2021 • May 14, 2021
This study investigates the role of CtBP and Snail in tumor invasion using Drosophila as a model organism. The researchers found that both CtBP and Snail are required for tumor growth and invasion tri...
KEY FINDING: Depletion of CtBP or Snail (Sna) suppressed RasV12/lgl-/--triggered tumor growth and invasion, and disrupted cell polarity-induced invasive cell migration in Drosophila.
Current Neuropharmacology, 2022 • January 1, 2022
This review summarizes current knowledge about four epigenetic modifications—DNA/RNA methylation, histone acetylation, and circRNAs—in chronic pain. Epigenetic modifications may shed lights on the chr...
KEY FINDING: DNA methylation, mediated by enzymes like DNMTs and TETs, plays a role in chronic pain development. Specifically, the upregulation of methyltransferase DNMT3a is widely involved in chronic pain induced by a variety of causes, and it promotes the occurrence and development of chronic pain by inhibiting the transcription of analgesic-related genes by increasing the methylation level of these genes.
The Journal of Neuroscience, 2021 • October 13, 2021
This study investigates the role of astrocyte CD38 in myelin injury and regeneration, focusing on the impact of high-fat diets on oligodendrocytes and myelin integrity. The findings demonstrate that h...
KEY FINDING: High-fat diet consumption increases CD38 expression in astrocytes, leading to NAD1 depletion in the spinal cord.
BIOENGINEERED, 2021 • August 4, 2021
This study investigates the role of circSMEK1 in neuropathic pain (NP) using rat and cell models. The results indicate that circSMEK1 and TXNIP are upregulated in NP, while miR-216a-5p is downregulate...
KEY FINDING: CircSMEK1 and TXNIP are upregulated in neuropathic pain (NP), while miR-216a-5p is downregulated.
Journal of Neuroinflammation, 2021 • September 2, 2021
This study investigates the role of Heat shock transcription factor 1 (HSF1) in suppressing the conversion of A1 astrocytes following spinal cord injury (SCI) in rats. The results showed that HSF1 pro...
KEY FINDING: HSF1 protein levels increase in astrocytes after spinal cord injury in rats, showing colocalization with astrocytes at lesion sites.
Scientific Reports, 2021 • September 22, 2021
This study aimed to characterize the evolution of the cutaneous microbiota of pressure ulcers (PU) in a spinal cord injury (SCI) cohort, analyzing tissue biopsies at baseline and 28 days using 16S rRN...
KEY FINDING: Wounds with a 'Stagnated/Worsened' evolution had a significantly higher relative abundance of Anaerococcus and Finegoldia at baseline (D0).
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • July 8, 2021
This study aimed to investigate the neuroprotective and autophagic effects of IGF‑1 on SCI, and to determine the role of the PI3K/Akt/mTOR signaling pathway in this process. The results of the present...
KEY FINDING: IGF-1 significantly increased cell survival in vitro compared to the control group, suggesting a protective effect on nerve cells.
Curr Biol, 2021 • November 22, 2021
This study investigates the genetic mechanisms underlying the evolutionary transition from preaxial to postaxial limb polarity, focusing on the role of Gli3R activity. Experiments in mice and axolotls...
KEY FINDING: Deletion of 5’Hoxd genes in mice leads to preaxial dominant limb formation, an ancestral trait.
J Cell Mol Med, 2021 • September 19, 2021
This study investigates the inhibitory effect of EV-miRNA-22 on the inflammatory response in spinal cord injury (SCI) in rats. The researchers loaded mesenchymal stem cells (MSCs)-EV with miRNA-22...
KEY FINDING: EV-miRNA-22 could inhibit the occurrence of pyroptosis in microglia, suppress the cell membrane pore opening, and inhibit the release of inflammatory factors and the expression of GSDMD.
PLOS ONE, 2021 • October 14, 2021
This study investigated gene expression changes in the vastus lateralis muscle following different strength training regimes (CON/ECC+ and CON/ECC) during rehabilitation after ACL-R. The results indic...
KEY FINDING: Significant changes were detected in the expression of 26 mRNAs, several of them involved in muscle wasting/atrophy, indicating ongoing muscle remodeling processes.