J Cell Mol Med, 2021 · DOI: 10.1111/jcmm.16965 · Published: September 19, 2021
Spinal cord injury (SCI) can cause severe dyskinesia and sensory disturbance. Inflammation caused by inflammatory factors can lead to secondary damage. The mechanism of inflammatory response of SCI is relatively complicated, involving both nerve cell injury and the participation of the immune system. Mesenchymal stem cells (MSCs) can repair the nerve function injury of SCI to a certain extent, promote the regeneration of nerve axons and enhance the repair of motor nerves as well as functional repair. However, the transplantation of MSCs may cause side effects such as tissue immune rejection, teratogenesis, and tumorigenesis EV are vesicle-like structures secreted by cells. Studies have found that the EV derived from MSCs also exert good effects on the nerve repair of SCI. In addition, MSC-derived EV greatly attenuate the various side effects caused by MSCs. Therefore, in this study, miRNA-22 was loaded into the MSC-derived EV, which was speculated to promote the regeneration of nerve cells and inhibit neuroinflammation, thereby playing a synergistic role.
EV-miRNA-22 shows good therapeutic potentials for SCI mainly by cooperating with MSCs-EV, suggesting a new avenue for SCI treatment.
The study highlights the importance of inhibiting inflammation, particularly pyroptosis, in managing SCI.
Targeting microglia activation with EV-miRNA-22 can reduce inflammatory factors and improve nerve function recovery.