Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 601-610 of 1,773 results
Frontiers in Cell and Developmental Biology, 2021 • October 15, 2021
The review highlights the complexity of the genetic system involved in central axon regeneration after SCI. Some genes active during development, such as KLF7, SOX11 and STAT3, are potential therapeut...
KEY FINDING: Corticospinal motor neurons (CSMNs) exhibit limited regeneration ability after spinal cord injury compared to other pathways in the central nervous system.
Neurotrauma Reports, 2021 • January 1, 2021
This study investigated the role of microRNAs (miRNAs) in neuropathic pain following spinal cord injury (SCI) by screening miRNA expression in plasma samples from individuals with and without SCI. The...
KEY FINDING: 383 miRNAs were differentially expressed in acute or chronic SCI versus no SCI.
Microbial Biotechnology, 2022 • May 1, 2022
This study investigated the effects of electroacupuncture (EA) on gut microbial dysbiosis and the 5-HT system in spinal cord injury (SCI) rats. EA and fecal microbiota transplantation (FMT) improved i...
KEY FINDING: EA and FMT treatment facilitated intestinal transmission functional recovery and restored the colon morphology of SCI rats.
Redox Biology, 2022 • January 1, 2022
This study investigates the role of Dynamin-related protein 1 (Drp1), a key regulator of mitochondrial fission, in neuropathic pain (NP) using a spared nerve injury (SNI) model in mice. The research f...
KEY FINDING: SNI in mice induces pain behavior and anxiety-like behavior, which is associated with elevation of Drp1, as well as increased density of mitochondria in SDH.
Journal of Cachexia, Sarcopenia and Muscle, 2022 • January 9, 2022
This study demonstrates that Numb protein levels decline with age in skeletal muscle. The loss of Numb in skeletal muscle fibers leads to reduced contractile function, altered sarcomere length, and de...
KEY FINDING: Numb protein expression decreases significantly with age in mouse skeletal muscle.
Frontiers in Bioengineering and Biotechnology, 2022 • January 4, 2022
This study investigates the potential of GDF11, delivered via a lentiviral vector, to promote nerve regeneration after sciatic nerve injury in rats. The findings demonstrate that GDF11 promotes axonal...
KEY FINDING: GDF11 promotes the axonal growth of DRG cells in vitro, suggesting a direct effect on nerve regeneration.
Neural Regeneration Research, 2022 • September 1, 2022
CSPGs inhibit axon regeneration after SCI by interacting with receptors like PTPσ, LAR, and NgRs, activating RhoA and inactivating Akt signaling pathways. ChABC treatment can remove CSPGs, reactivate ...
KEY FINDING: Digestion of CSPGs with ChABC reduces retrograde apoptotic signaling and enhances true axon regeneration in lampreys after spinal cord transection.
Journals of Gerontology: Biological Sciences, 2022 • October 1, 2022
This study characterized the effects of laparotomy on postoperative physical function and skeletal muscle gene expression in male C57BL/6N mice across life span. The study found that laparotomy-induce...
KEY FINDING: Laparotomy induced an age-associated postoperative decline in forelimb grip strength, with the greatest decline in the oldest mice.
BMC Research Notes, 2022 • February 9, 2022
This study investigates the impact of gut microbiota modulation on functional recovery after traumatic peripheral nerve injury (TPNI) in mice. Using antibiotic (ABX)-induced dysbiosis and probiotic (P...
KEY FINDING: Antibiotic (ABX) treatment before a peripheral nerve injury significantly impaired functional recovery in mice.
Frontiers in Physiology, 2022 • February 10, 2022
This study investigated the relationship between visceral adiposity, inflammation, testosterone, and mitochondrial health in individuals with chronic spinal cord injury (SCI). The study found that incr...
KEY FINDING: Citrate synthase (CS) activity, a measure of mitochondrial mass, was negatively associated with visceral adipose tissue (VAT) and C-reactive protein (CRP), an inflammatory marker.