Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 581-590 of 1,773 results
CNS Neuroscience & Therapeutics, 2025 • March 5, 2025
This letter to the editor provides comments on a research article concerning the role of H4K12 lactylation in promoting Spp1 transcription and aiding functional recovery post-spinal cord injury (SCI)....
KEY FINDING: The original study demonstrated the significant role of recombinant Spp1 protein (rSPP1) in functional recovery after spinal cord injury.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This case report highlights a case of spinal cord infarction (SCI) in a young adult, emphasizing the role of genetic mutations in such events and the importance of early genetic testing. The study sug...
KEY FINDING: The patient had multiple heterozygous and homozygous gene mutations, including factor II G20210A, MTHFR A1298C, factor XIII, beta-fibrinogen, and ACE D-allele.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This study compared the effects of intensity-matched acute exercise on inflammatory markers between able-bodied (AB) and spinal cord injured (SCI) individuals. SCI individuals exhibited a consistently...
KEY FINDING: The SCI group had higher levels of interleukin-2 (IL-2) and lower levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) at all measurement times compared to the AB group.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
The study investigated the association between ibuprofen use and systemic inflammation markers (CRP and IL-6) in individuals with chronic SCI. Results indicated that ibuprofen use was associated with ...
KEY FINDING: Ibuprofen users had significantly lower CRP levels (2.3 mg/L versus 3.5 mg/L, P = 0.04) compared to nonusers after adjusting for clinical and demographic factors.
Neural Regen Res, 2021 • September 1, 2021
The study investigated the role of HMGB1 in the inflammatory response of astrocytes following spinal cord injury (SCI) in rats using transcriptome sequencing and in vitro experiments. The results show...
KEY FINDING: HMGB1/TLR4 axis is involved in astrocyte inflammatory response through regulation of COX2/PGE2 signaling.
Glia, 2021 • September 1, 2021
This study demonstrates that genetic knockout of PAR1 in mice improves sensorimotor outcomes and neural repair after spinal cord injury. The improved outcomes are associated with reduced inflammation,...
KEY FINDING: Genetic blockade of PAR1 in female mice results in improvements in sensorimotor co-ordination after thoracic spinal cord lateral compression injury.
Dev Dyn, 2022 • June 1, 2022
This paper addresses the critical need for standardized gene and transgenic nomenclature in axolotl research. Recent advancements in genetic and molecular tools have greatly accelerated work with axol...
KEY FINDING: The paper proposes a set of guidelines for gene and transgenic nomenclature in the axolotl, covering species symbols, gene/mRNA/cDNA, protein naming, paralogs/orthologs, novel genes, transcript variants, non-coding transcripts, and mitochondrial genes.
Redox Biology, 2021 • April 22, 2021
This study investigates the mechanism of motor neuron death following spinal cord injury (SCI), focusing on the role of iron overload and ferroptosis in the motor cortex. The study demonstrates that S...
KEY FINDING: SCI induces iron overload in the motor cortex of both human patients and rat models.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • February 2, 2021
This study demonstrated that inhibiting STAT3 not only promoted NSC differentiation into neurons, but also inhibited their differentiation into astrocytes, potentially through mTOR activation. The tra...
KEY FINDING: Knocking down STAT3 expression in rat NSCs promoted their neuronal differentiation in vitro, and upregulated the activity of mTOR.
Biomed Pharmacother, 2021 • August 1, 2021
The review highlights the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in stroke pathophysiology and recovery. Exosomes, as nanocarriers, transpor...
KEY FINDING: LncRNAs like MALAT1, ANRIL, and H19 affect angiogenesis, inflammation, autophagy and apoptosis following ischemic stroke.