Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 571-580 of 1,773 results
Scientific Reports, 2024 • December 2, 2024
This study investigates the role of bone marrow mesenchymal stem cells (BMMSCs) and miR-202-3p in treating spinal cord injury (SCI) in rats. The research demonstrates that BMMSCs, mediated by miR-202-...
KEY FINDING: BMMSCs improve motor function recovery in SCI rats, as evidenced by increased BBB scores and improved footprint analysis.
European Journal of Medical Research, 2024 • January 1, 2024
The study investigated the mechanism by which pulsed radiofrequency (PRF) alleviates neuropathic pain (NP) in a rat model of chronic constriction injury (CCI). PRF treatment was found to alleviate NP ...
KEY FINDING: PRF treatment alleviated NP in CCI rats, and upregulated the expression of MG53 while inhibiting microglial activation.
CANCER BIOLOGY & THERAPY, 2024 • December 3, 2024
This study investigates the efficacy of dinaciclib, a Cdk inhibitor, in treating biliary tract cancer (BTC) using in vitro models. The findings indicate that dinaciclib reduces cell viability, ATP lev...
KEY FINDING: Dinaciclib reduces cell viability, ATP levels, and proliferation rates in BTC cells.
Journal of Cellular and Molecular Medicine, 2025 • January 1, 2025
This study investigates the potential therapeutic role of resveratrol (RES) and miR-124-3p in mitigating pyroptosis and promoting recovery from spinal cord injury (SCI). The research demonstrates that...
KEY FINDING: DAPK1 interacts with NLRP3, promoting pyroptosis via the NLRP3/Caspase-1/GSDMD pathway. Knocking down DAPK1 inhibits pyroptosis.
Cell & Bioscience, 2025 • January 23, 2025
This study demonstrates that trehalose enhances myelin debris clearance and reduces foamy macrophage formation after SCI by inducing TFEB expression in macrophages and modulating the autophagy-lysosom...
KEY FINDING: Trehalose enhances macrophage phagocytosis and clearance of myelin debris in a dose-dependent manner in vitro, with an optimal concentration of 20 mM.
Frontiers in Immunology, 2025 • January 15, 2025
This study demonstrates that low-level spinal cord injury (SCI) enhances lung inflammation and immune responses in mice exposed to lipopolysaccharide (LPS), mimicking a bacterial infection. SCI amplif...
KEY FINDING: Spinal cord injury (SCI) at the T9 level amplifies lung inflammation in mice following exposure to lipopolysaccharide (LPS), as evidenced by increased pro-inflammatory gene expression and cytokine release.
Journal of Neuroinflammation, 2025 • January 27, 2025
This study demonstrates a significant upregulation of C/EBPβ in microglia in a mouse model of SCI, suggesting its involvement in the post-SCI neuroinflammatory response. The research uncovers that C/E...
KEY FINDING: C/EBPβ is significantly upregulated in microglia after spinal cord injury in mice and is associated with neuroinflammation.
Neurochemical Research, 2025 • January 16, 2025
This study investigates the mechanisms underlying neuropathic pain (NP), focusing on the role of mTOR in astrocytes. It finds that mTOR is activated in astrocytes following chronic constriction injury...
KEY FINDING: mTOR is activated in astrocytes within the spinal cord following chronic constriction injury (CCI), contributing to neuropathic pain.
PLOS ONE, 2025 • February 27, 2025
This study investigated the role of anoikis-related genes in neuropathic pain (NP), particularly in lumbar disc herniation (LDH). Machine learning algorithms identified six key genes (HGF, MMP13, ABL1...
KEY FINDING: Six key anoikis-related genes (HGF, MMP13, ABL1, ELANE, FASN, and LINC00324) were identified as having diagnostic value for NP.
Journal of Neuroinflammation, 2025 • February 14, 2025
This study investigates the microglial response from subacute to chronic cervical SCI in rats, finding distinct microglial signatures that overlap between the subacute and chronic periods. The subacut...
KEY FINDING: Subacute SCI is characterized by a disease-associated microglial (DAM) signature, while chronic SCI is highly heterogeneous, with both injury-induced and homeostatic states.