Genetics Research

KEY FINDING: Wnt/β-catenin signaling reporter TOPgal positive cells appeared at the lesion site by 5 days, peaked on 7 days, and diminished by 14 days post injury.

KEY FINDING: D-DT expression is induced in astrocytes and neurons, but not microglia, following spinal cord contusion, indicating a cell-specific response to injury.

KEY FINDING: Salivary and lacrimal glands contain cells derived from all three germ layers (ectoderm, mesoderm, and endoderm).

KEY FINDING: ASIC1A is upregulated in NSCs following spinal cord injury.

KEY FINDING: Zinc deficiency after SCI promotes the translocation of NF-kB in macrophages, leading to a pro-inflammatory phenotype and increased expression of pro-inflammatory cytokines.

KEY FINDING: For every 1 g/L increase in fibrinogen level, the risk of developing PI increased by 18% (HR = 1.18, P = 0.011), and indicating a positive linear relationship between fibrinogen level and PI incidence.

KEY FINDING: KHES significantly alleviated mechanical and thermal allodynia in neuropathic pain mice, demonstrating its potential as a treatment.

KEY FINDING: NMN supplementation restores NAD+ levels after SCI, promoted motor function recovery, and alleviated pain in a mouse model.

KEY FINDING: Mitochondrial dysfunction is intimately linked with axonal regeneration failure in the context of spinal cord injury.

KEY FINDING: MSCs can regulate macrophage polarization by secreting soluble proteins, including ILs and chemokines, which ultimately relieve SCI.