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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Genetics Research

Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.

Showing 481-490 of 1,773 results

Spinal Cord InjuryGeneticsResearch Methodology & Design

Fibronectin Matrix Assembly after Spinal Cord Injury

JOURNAL OF NEUROTRAUMA, 2015 • August 1, 2015

This study investigates the mechanism of fibrotic scar formation after spinal cord injury (SCI), focusing on fibronectin matrix assembly. The findings indicate that fibronectin starts forming a matrix...

KEY FINDING: Fibroblasts are the major source of fibronectin in the fibrotic scar after spinal cord injury. Deletion of fibronectin in myeloid cells did not change fibronectin expression level, indicating that fibroblasts are likely the major source.

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HealthcareGeneticsBiomedical

Large-scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Journal of Extracellular Biology, 2022 • September 14, 2022

The “massivEVs” workshop focused on the challenges and potential solutions for large-scale EV production, bringing together experts from academia and industry. Key areas discussed included manufacturi...

KEY FINDING: EV purity may not always correlate with functionality, and co-isolates could contribute to function and stability.

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Spinal Cord InjuryGeneticsResearch Methodology & Design

Mitomycin C induces apoptosis in human epidural scar fibroblasts after surgical decompression for spinal cord injury

Neural Regeneration Research, 2017 • April 1, 2017

The study investigates the mechanism by which mitomycin C (MMC) reduces scar adhesion after surgical decompression for spinal cord injury, focusing on its effect on human epidural scar fibroblasts (HE...

KEY FINDING: MMC suppresses the growth of human epidural scar fibroblasts in a dose- and time-dependent manner.

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Spinal Cord InjuryGeneticsResearch Methodology & Design

Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism

Frontiers in Cellular Neuroscience, 2021 • August 26, 2021

This review summarizes the current understanding of fibrotic scar formation after spinal cord injury (SCI), its cellular origins, and its interactions with other cells in the injured area. It highligh...

KEY FINDING: Fibrotic scar tissue, composed of fibroblasts and excess extracellular matrix, forms after SCI and inhibits axonal regeneration.

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Spinal Cord InjuryPhysiologyGenetics

Expression of Hyaluronidase-4 in a Rat Spinal Cord Hemisection Model

Asian Spine Journal, 2015 • February 1, 2015

This study examined the expression of Hyal-4 in a rat spinal cord hemisection model to understand its role in CSPG degradation after injury. The results showed that CSPGs peaked at 3 weeks post-injury...

KEY FINDING: CSPGs appeared at the injury site at 4 days after hemisection, reached a peak after 3 weeks, and then decreased.

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Regenerative MedicineGenetics

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Attenuates Experimental Periodontitis in Mice Partly by Delivering miRNAs

International Journal of Nanomedicine, 2025 • March 8, 2025

The study successfully constructed a hydrogel-loaded lyophilized hucMSCs-exo drug delivery system, which is called exo@H, and demonstrated its effectiveness in treating periodontitis in mice. Exo@H pr...

KEY FINDING: Lyophilized hucMSCs-exo promoted the proliferation and osteogenic differentiation of MC3T3-E1 cells, and showed more significant abilities in combination with hydrogel.

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GeneticsResearch Methodology & Design

Scleraxis expressing scleral cells respond to inflammatory stimulation

Histochemistry and Cell Biology, 2021 • May 8, 2021

This study characterized scleral cells and examined their response to inflammatory stimulation using an ex vivo model. The research demonstrated that scleral cells express tendon-associated markers an...

KEY FINDING: Scleral cells express tendon-associated markers such as scleraxis, tenomodulin and mohawk.

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Spinal Cord InjuryGeneticsResearch Methodology & Design

Correction to: Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Signal Transduction and Targeted Therapy, 2022 • January 1, 2022

This article is a correction notice for a paper that investigated cellular and molecular changes in the spinal cord after injury. The corrections address errors in figure presentations, specifically t...

KEY FINDING: The original article mistakenly switched “4h” and “1d” UMAP plots in Fig. 2g.

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PharmacologyRegenerative MedicineGenetics

Chemical Genetics of Regeneration: Contrasting Temporal Effects of CoCl2 on Axolotl Tail Regeneration

Dev Dyn, 2021 • June 1, 2021

This study investigates the effects of CoCl2, a chemical that induces hypoxia and cellular stress, on axolotl tail regeneration, particularly in the context of romidepsin-induced regeneration inhibiti...

KEY FINDING: CoCl2 can partially rescue the inhibitory effect of romidepsin on tail regeneration when co-administered for 1 minute post-amputation (MPA).

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PhysiologyGeneticsBioinformatics

Exploration of molecular pathways mediating electric field-directed Schwann cell migration by RNA-Seq

J Cell Physiol, 2015 • July 1, 2015

This study investigates the migration of Schwann cells in electric fields (EFs), finding that they migrate towards the anode, with increased directedness and displacement at higher EF strengths. RNA s...

KEY FINDING: Schwann cells migrate towards the anode in an applied electric field, and the directedness and displacement of migration increase with the strength of the electric field.

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