Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 481-490 of 1,773 results
JOURNAL OF NEUROTRAUMA, 2015 • August 1, 2015
This study investigates the mechanism of fibrotic scar formation after spinal cord injury (SCI), focusing on fibronectin matrix assembly. The findings indicate that fibronectin starts forming a matrix...
KEY FINDING: Fibroblasts are the major source of fibronectin in the fibrotic scar after spinal cord injury. Deletion of fibronectin in myeloid cells did not change fibronectin expression level, indicating that fibroblasts are likely the major source.
Journal of Extracellular Biology, 2022 • September 14, 2022
The “massivEVs” workshop focused on the challenges and potential solutions for large-scale EV production, bringing together experts from academia and industry. Key areas discussed included manufacturi...
KEY FINDING: EV purity may not always correlate with functionality, and co-isolates could contribute to function and stability.
Neural Regeneration Research, 2017 • April 1, 2017
The study investigates the mechanism by which mitomycin C (MMC) reduces scar adhesion after surgical decompression for spinal cord injury, focusing on its effect on human epidural scar fibroblasts (HE...
KEY FINDING: MMC suppresses the growth of human epidural scar fibroblasts in a dose- and time-dependent manner.
Frontiers in Cellular Neuroscience, 2021 • August 26, 2021
This review summarizes the current understanding of fibrotic scar formation after spinal cord injury (SCI), its cellular origins, and its interactions with other cells in the injured area. It highligh...
KEY FINDING: Fibrotic scar tissue, composed of fibroblasts and excess extracellular matrix, forms after SCI and inhibits axonal regeneration.
Asian Spine Journal, 2015 • February 1, 2015
This study examined the expression of Hyal-4 in a rat spinal cord hemisection model to understand its role in CSPG degradation after injury. The results showed that CSPGs peaked at 3 weeks post-injury...
KEY FINDING: CSPGs appeared at the injury site at 4 days after hemisection, reached a peak after 3 weeks, and then decreased.
International Journal of Nanomedicine, 2025 • March 8, 2025
The study successfully constructed a hydrogel-loaded lyophilized hucMSCs-exo drug delivery system, which is called exo@H, and demonstrated its effectiveness in treating periodontitis in mice. Exo@H pr...
KEY FINDING: Lyophilized hucMSCs-exo promoted the proliferation and osteogenic differentiation of MC3T3-E1 cells, and showed more significant abilities in combination with hydrogel.
Histochemistry and Cell Biology, 2021 • May 8, 2021
This study characterized scleral cells and examined their response to inflammatory stimulation using an ex vivo model. The research demonstrated that scleral cells express tendon-associated markers an...
KEY FINDING: Scleral cells express tendon-associated markers such as scleraxis, tenomodulin and mohawk.
Signal Transduction and Targeted Therapy, 2022 • January 1, 2022
This article is a correction notice for a paper that investigated cellular and molecular changes in the spinal cord after injury. The corrections address errors in figure presentations, specifically t...
KEY FINDING: The original article mistakenly switched “4h” and “1d” UMAP plots in Fig. 2g.
Dev Dyn, 2021 • June 1, 2021
This study investigates the effects of CoCl2, a chemical that induces hypoxia and cellular stress, on axolotl tail regeneration, particularly in the context of romidepsin-induced regeneration inhibiti...
KEY FINDING: CoCl2 can partially rescue the inhibitory effect of romidepsin on tail regeneration when co-administered for 1 minute post-amputation (MPA).
J Cell Physiol, 2015 • July 1, 2015
This study investigates the migration of Schwann cells in electric fields (EFs), finding that they migrate towards the anode, with increased directedness and displacement at higher EF strengths. RNA s...
KEY FINDING: Schwann cells migrate towards the anode in an applied electric field, and the directedness and displacement of migration increase with the strength of the electric field.