Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 281-290 of 1,773 results
Cell and Tissue Research, 2023 • November 16, 2022
This review discusses the interaction between autophagy and exosomes from the perspective of molecular mechanisms, which might provide novel insights for the early therapeutic application of spinal co...
KEY FINDING: Exosomes and autophagy play critical roles in cellular homeostasis following spinal cord injury.
Orthopaedic Surgery, 2023 • January 1, 2023
This study investigates the role of LINC00665 in osteosarcoma (OS) cells, revealing its significant up-regulation and cancer-promoting function. It demonstrates that LINC00665 promotes OS cell prolife...
KEY FINDING: LINC00665 is significantly upregulated in OS cells compared to normal bone cells, suggesting its involvement in OS development.
Heliyon, 2022 • October 20, 2022
The study investigates the effect of Erxian Decoction (EXD) on spinal cord injury (SCI) repair in rats, focusing on the underlying molecular mechanisms. The research demonstrates that EXD significantl...
KEY FINDING: EXD improved motor function at 7 days post-injury (dpi) in SCI rats.
Neurotherapeutics, 2023 • November 18, 2022
This study investigates the potential of localized delivery of combinative shRNAs via LV to suppress the expression of specific genes with a favorable risk–benefit ratio, thereby alleviating neuropath...
KEY FINDING: The expression level of TNFa was significantly decreased in LV-shP38 (16.75 ± 3.4 pg/ml) and LV-shP38/shTRPA1 (17.01 ± 2.7 pg/ml) compared to LV-NC (27.50 ± 3.07 pg/ml, P < 0.01) or LV-shTRPA1 (29.75 ± 3.52 pg/ ml, P < 0.01).
Frontiers in Medicine, 2022 • November 3, 2022
Traumatic brain injury and spinal cord injury lead to inflammation and oxidative stress, with microglia playing a key role through ROS production from NOX, mitochondria, and altered iron levels. Targe...
KEY FINDING: Microglial depletion studies suggest that delayed depletion using PLX5622 reduced microglial ROS and improved outcomes after spinal cord injury, implying that timing is critical for therapeutic efficacy.
Frontiers in Cellular Neuroscience, 2024 • June 26, 2024
This study introduces a novel ex vivo model using rat longitudinal spinal cord slice cultures to study demyelination and remyelination. The model demonstrates that LPC effectively induces demyelinatio...
KEY FINDING: Rat longitudinal spinal cord slices can be cultured for up to 6 weeks ex vivo while retaining anatomical structure and myelination.
Heliyon, 2024 • June 13, 2024
The study aimed to verify the analgesic effect of intravenous administration of human umbilical cord mesenchymal stem cells (HUC-MSCs) upon rats with chronic constriction injury (CCI)-induced neuropat...
KEY FINDING: Intravenous administration of HUC-MSCs significantly ameliorated CCI-induced mechanical allodynia and thermal hyperalgesia in rats.
MOLECULAR MEDICINE REPORTS, 2024 • June 18, 2024
The review explains the classification and functions of lncRNAs and their roles in IDD, AS and SCI, noting their impact on ECM, cell death, inflammation, and aging in spinal diseases. Thousands of lnc...
KEY FINDING: lncRNAs are involved in the occurrence and development of spinal diseases, including IDD, ankylosing spondylitis, and spinal cord injury.
Cell & Bioscience, 2022 • November 3, 2022
The study aimed to develop non-metabolizable pregnenolone (P5) analogs to differentiate the effects of P5 from its metabolites in treating neurodevelopmental diseases. Compound #43 was identified as a...
KEY FINDING: Compound #43 (3-beta-pregnenolone acetate) increases microtubule polymerization in vitro and modifies microtubule dynamics in live cells.
British Journal of Anaesthesia, 2023 • November 24, 2022
This study examined the effect of intrathecal injection of NIS-lncRNA antisense oligonucleotides on neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve, spinal nerve liga...
KEY FINDING: Intrathecal NIS-lncRNA antisense oligonucleotides attenuated CCI-induced mechanical allodynia, heat hyperalgesia, cold hyperalgesia, and ongoing nociceptive responses, without changing basal or acute nociceptive responses and locomotor function.