Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 271-280 of 1,773 results
Int. J. Mol. Sci., 2022 • September 24, 2022
This study investigates the role of AhR in neuropathic pain using nerve explant cultures and a CCI model in mice. The findings suggest that AhR agonists could be potential candidates for neuropathic p...
KEY FINDING: Deletion of AhR aggravated nerve damages and this was restored by omeprazole, indicating a protective role of AhR in nerve health.
Physiol. Res., 2022 • October 13, 2022
This mini-review aims to introduce the association between Secretory clusterin/apolipoprotein J (sCLU) and diverse musculoskeletal diseases. Recent findings of sCLU in these musculoskeletal diseases p...
KEY FINDING: sCLU is associated with inflammatory responses, tissue degeneration, and cellular apoptosis during acute and subacute traumatic SCI.
Biomedicines, 2022 • September 21, 2022
This study used a rat model of spinal cord injury (SCI) induced by cryoinjury to evaluate histological, bioimaging, and cytokine data. The goal was to find noninvasive methods for evaluating the thera...
KEY FINDING: Plasma levels of IL-1α, IL-1β, TNFα, GRO/KC, G-CSF, IFNγ and IL-13 may be considered as a reliable prognostic index for SCI.
Molecular Neurobiology, 2023 • October 24, 2022
Spinal cord injury (SCI) is a major traumatic disease of the central nervous system characterized by high rates of disability and mortality. Exosomes are membrane-bound vesicles with a diameter of onl...
KEY FINDING: Exosome-loaded miRNAs can aid the recovery of SCI in experimental mice, including the ability to promote neuronal recovery, inhibit apoptosis, promote axonal regeneration, modulate the inflammatory response, and promote angiogenesis, as well as to regulate microglia and macrophages.
CNS Neuroscience & Therapeutics, 2023 • January 1, 2023
This study aimed to evaluate the effects of the depletion of SAM and SH3 domain-containing protein 1 (SASH1) on functional recovery after spinal cord injury (SCI) and to investigate the possible mecha...
KEY FINDING: SASH1 knockdown improved the BBB scores after SCI and significantly reduced GFAP expression.
Neurochemical Research, 2022 • October 26, 2022
The study aimed to investigate the effects of linalyl acetate (LA) on neuropathic pain caused by sciatic nerve injury (SNI) in rats, focusing on the TSLP and IL-33 signaling pathways. The results show...
KEY FINDING: LA attenuated mechanical hyperalgesia in SNI rats, indicating a reduction in pain sensitivity.
Brain Sci., 2022 • September 29, 2022
This study investigates the pro-angiogenesis of M2 macrophage-derived exosomes on SCI. The findings reveal that M2 macrophage exosomes improve neurological functional recovery and angiogenesis post-SC...
KEY FINDING: M2 macrophage exosomes alleviate tissue damage and enhance functional recovery post-SCI in rats.
PNAS, 2022 • November 2, 2022
This study identifies Tmem45b as a crucial molecule for inflammation- and tissue injury-induced mechanical pain hypersensitivity. Tmem45b is mainly expressed in IB4+ sensory neurons. Tmem45b-knockout ...
KEY FINDING: IB4+ sensory neurons are selectively involved in inflammation- and tissue injury–induced mechanical pain hypersensitivity, but not in neuropathic pain.
Journal of Pain Research, 2022 • October 25, 2022
Our study suggests that CONPs can relive the NP following SCI by promoting M2 macrophages polarization, which provides a novel insight for the treatment of SCI induced NP. Many researchers in the SCI ...
KEY FINDING: The synthesized CONPs were 6.8 ± 0.5 nm in size, presenting a cubic morphology.
Journal of Neuroinflammation, 2022 • November 16, 2022
This study demonstrates that AR expression is markedly upregulated in the BPRA mice model. Genetic knockout or epalrestat pharmacological suppression of AR contributed to better MNs survival by attenu...
KEY FINDING: AR upregulation in the spinal cord correlated with inactivated SIRT1–AMPK–mTOR pathway and disrupted autophagy following BPRA.