Genetics Research

KEY FINDING: This paper reports the first documented case of myasthenia gravis occurring in a patient with achondroplasia.

KEY FINDING: The study identified significant differences in gene expression between the two SCI models, particularly within the first two weeks after injury.

KEY FINDING: Triad1 overexpression promoted PTN protein levels, NGF expression, BDNF expression, astrocyte and neuronal viability, and neurite outgrowth but suppressed astrocyte apoptosis.

KEY FINDING: MiR-31 promotes the proliferation of BMSCs in vitro, as demonstrated by CCK-8 and Cell-cycle assays.

KEY FINDING: Inflammation following SCI is a complex process with both beneficial and detrimental effects, requiring careful modulation for effective treatment.

KEY FINDING: Treatment with rhEPO and cEPO-Fc significantly improves the neurological outcome of mice after spinal cord ischemia.

KEY FINDING: Mesenchymal stem cell (MSC) exosomes participate in tissue repair and injury processes, suggesting their potential as drug carriers. Macrophage-derived exosomes can affect the tissue microenvironment by modulating immune function and tend to accumulate in cancer cells due to specific surface proteins.

KEY FINDING: SMA patients exhibit retinal vascular defects, characterized by a less dense and less complex primary retinal vasculature compared to age-matched controls.

KEY FINDING: RIPK1, RIPK3, and MLKL expression increases in the hours to days after TBI, but the temporal patterns of these proteins differ between SCI and TBI.

KEY FINDING: Melatonin promotes the recovery of neuromotor function by inhibiting neuroinflammation and reducing neuronal death.