Genetics Research

KEY FINDING: Autophagy plays a significant role in maintaining the homeostasis of corpus cavernosum endothelial cells (CCECs) and determining their survival and death, influencing ED, particularly in diabetes mellitus-induced ED (DMED).

KEY FINDING: After spinal cord injury, microglia polarize into pro-inflammatory phenotypes (MG1 and MG3), while astrocytes polarize into reactive and scar-forming phenotypes, with Gas6 and Axl expression significantly down-regulated in both cell types.

KEY FINDING: SHP2 expression is upregulated in microglia at the site of spinal cord injury and in LPS-induced microglia.

KEY FINDING: 3745 mRNAs and 738 lncRNAs were differentially methylated with m6A modifications in the SCI and sham rats.

KEY FINDING: The CCL2/CCR2 axis recruits immune cells to the injury site, stimulating microglia and macrophages, which exacerbates the inflammatory response and nerve damage, worsening SCI.

KEY FINDING: Oligodendrocyte loss or dysfunction contributes to neuropathic pain following peripheral nerve injury, spinal cord injury, chemotherapy, and HIV infection.

KEY FINDING: Pharmacological activation of spinal mTORC2 induces pain hypersensitivity.

KEY FINDING: Chetomin administration 8h post-injury decreased IL-6 and VEGF expression.

KEY FINDING: Spinal hdac3, hdac4, and hdac6 were upregulated in CCI rats, indicating their potential role in neuropathic pain.

KEY FINDING: Bmal1 inhibits NLRP3 inflammasome activation and microglial pyroptosis after SCI both in vitro and in vivo.