Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 161-170 of 1,773 results
Neural Regeneration Research, 2014 • July 1, 2014
This study investigated the neuroprotective effects of green tea polyphenols on spinal cord neurons subjected to oxidative stress induced by hydrogen peroxide. The results showed that green tea polyph...
KEY FINDING: Green tea polyphenol treatment resulted in a dose-dependent decrease in malondialdehyde level in H2O2-injured spinal cord neurons.
Stem Cell Reports, 2014 • August 7, 2014
This study compares TALENs and CRISPRs for gene knockout in axolotls, finding CRISPRs to be more efficient and less toxic. Deletion of Sox2, a key neural stem cell gene, was achieved using CRISPR tech...
KEY FINDING: CRISPRs are more effective and less toxic than TALENs for gene knockout in axolotls, achieving higher knockout penetrance.
Journal of Cancer, 2014 • September 20, 2014
This review discusses the role of fibroblasts in salamander limb regeneration and contrasts their activity with that of human fibroblasts in wound healing and cancer. It examines how the salamander's ...
KEY FINDING: Salamander regeneration can reverse tumorigenicity, as demonstrated by the reversion of frog tumor cells to normal tissues in regenerating limbs.
PLoS ONE, 2014 • October 6, 2014
This study investigates the role of Nkx6.1, a transcription factor, in astrocyte development within the ventral spinal cord of mice. Using conventional and conditional Nkx6.1 mutant mice, researchers ...
KEY FINDING: Nkx6.1 is selectively expressed in ventral gray and white matter astrocytes in the developing spinal cord.
PLoS ONE, 2014 • October 8, 2014
The study investigates the three-dimensional structure of polylaminin (polyLM) and ordinary laminin (LM) using confocal fluorescence microscopy, scanning electron microscopy, and atomic force microsco...
KEY FINDING: Polylaminin (polyLM) forms a sponge-like network with homogeneous density, while ordinary laminin (LM) forms bulky protein aggregates.
J Neurol Surg B, 2014 • June 26, 2014
The olfactory mucosa is a specialized sensory organ for smell, and a better understanding of its cellular biology and physiology is necessary to appreciate experiments using animal models. The olfacto...
KEY FINDING: The human olfactory mucosa appears slightly yellow and lacks the distinctive hue seen in rodents, concentrated in the posterosuperior nasal cavity near the cribriform plate.
Neural Regeneration Research, 2014 • August 1, 2014
KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hippocampal and cortical neurons. Characterizing the molecular mechanisms of t...
KEY FINDING: KLF4 expression significantly decreased neurite outgrowth in hippocampal and cortical neurons, and RGCs.
Neural Regen Res, 2012 • November 1, 2012
This study investigated the effects of silencing the C/EBP homologous protein (CHOP) gene on acute brain injury following ischemia/reperfusion in rat models. The results showed that silencing CHOP sig...
KEY FINDING: Silencing C/EBP homologous protein gene expression significantly reduced cerebral infarction volume in rats following cerebral ischemia/reperfusion.
Nanoscale Advances, 2025 • January 7, 2025
This study explores the use of pyrroloquinoline quinone (PQQ) loaded on coaxial nanofibers as an implantable drug-delivery system to combat oxidative stress following spinal cord injury (SCI) in rats. ...
KEY FINDING: The concentration of NO and the activity of iNOS were significantly increased in the SCI group but were significantly decreased following treatment with nanofibers/PQQ.
Frontiers in Cellular Neuroscience, 2014 • October 9, 2014
Spinal motor neurons (SpMNs) are crucial for controlling muscles and movements. Their diversity is essential for precise motor control, and understanding this diversity is key to developing regenerati...
KEY FINDING: SpMNs are organized into distinct anatomical columns, each with a coherent gene expression profile and uniform axonal projection pattern.