Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 171-180 of 1,773 results
PLoS ONE, 2014 • October 28, 2014
The study aimed to elucidate the function of Olig3 in ventral spinal cord development, contrasting its known role in the dorsal spinal cord. Results indicated that Olig3 is expressed in post-mitotic n...
KEY FINDING: Olig3 is expressed in post-mitotic neurons in the ventral marginal zone of the developing spinal cord.
International Journal of Molecular Sciences, 2014 • October 28, 2014
The study aimed to evaluate whether combining ventral root reimplantation with bone marrow mononuclear cell (MC) therapy could improve long-term nerve regeneration and synaptic recovery after ventral ...
KEY FINDING: Root reimplantation preserves synaptic inputs, as shown by ultrastructural analysis of the spinal cord, leading to a close to normal synaptic covering compared to the avulsed group.
Neurotherapeutics, 2015 • November 5, 2014
The review discusses the role of localized protein synthesis in axons, highlighting its importance in both neuroregeneration and neurodegeneration. It explores how intra-axonal translation is reactiva...
KEY FINDING: Intra-axonal protein synthesis is crucial for growth cone behavior, axonal pathfinding, axon maintenance, and retrograde signaling in developing axons.
Frontiers in Neuroscience, 2014 • October 22, 2014
Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such as migration, dendrite developm...
KEY FINDING: RhoA/ROCK signaling is involved in various central nervous system (CNS) diseases, including optic nerve and spinal cord injuries, stroke, and neurodegenerative diseases.
Neural Regeneration Research, 2014 • September 1, 2014
This study explores the factors influencing the directional migration of bone marrow mesenchymal stem cells (BMSCs) towards injured spinal cord tissue, focusing on the role of microtubule-associated p...
KEY FINDING: The expression of P1-MAP1B in BMSCs is affected by okadaic acid (a protein phosphatase 2A inhibitor) and N-acetyl-D-erythro-sphingosine (a protein phosphatase 2A stimulator).
Neural Regen Res, 2014 • September 1, 2014
This study investigates the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors using a rat sciatic nerve crush model. The results indicate that edaravone promotes ...
KEY FINDING: Edaravone increased the sciatic functional index in rats with sciatic nerve injury, indicating improved motor function.
Cold Spring Harb Perspect Biol, 2015 • January 1, 2015
Astrocytes, the most abundant cell types in the mammalian brain, are now recognized as a functionally diverse population, challenging the notion of homogeneity. Regional and temporal factors contribut...
KEY FINDING: Adult V-SVZ astrocytes are regionally specified NSCs, with different regions generating specific subtypes of olfactory bulb interneurons, indicating a mosaic organization.
Frontiers in Neuroscience, 2014 • December 3, 2014
The blood-brain barrier (BBB) is a critical structure that regulates the passage of substances between the central nervous system and the bloodstream. Its dysfunction can lead to neurological disorder...
KEY FINDING: BBB formation is a complex process involving various cell types, including endothelial cells, astrocytes, neurons, glial cells, and pericytes, requiring their concerted action and interaction.
Neural Regen Res, 2012 • October 1, 2012
This study demonstrates that EG cells from primary culture release not only NGF and GDNF, but also BDNF, with their respective concentrations reaching 250, 96.4 and 53.8 pg/mL. Although NT-3 release c...
KEY FINDING: Primary enteric glia release nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor into culture medium.
Front Biol (Beijing), 2014 • October 1, 2014
After spinal cord injury (SCI), connections between neurons are severed, leading to neurological deficits. Understanding the adaptive responses to injury is crucial for targeted therapy to reestablish...
KEY FINDING: Histone deacetylases (HDACs) compact chromatin and generally exert a repressive transcriptional effect.