Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

Green tea polyphenols are strong antioxidants that can reduce free radical damage. This study explores their potential to protect spinal cord neurons from oxidative damage. The researchers induced oxidative damage in spinal cord neurons using hydrogen peroxide and then treated the cells with different concentrations of green tea polyphenol. The study found that green tea polyphenol effectively alleviated oxidative stress, indicating a protective role for these polyphenols in spinal cord neurons under oxidative stress.

• 1
  Green tea polyphenol treatment resulted in a dose-dependent decrease in malondialdehyde level in H2O2-injured spinal cord neurons.
• 2
  Superoxide dismutase activity was significantly lower after oxidative damage, but green tea polyphenol treatment led to a dose-dependent increase in its activity.
• 3
  Green tea polyphenol reduced the expression of apoptosis-related genes (Caspase-3 and Bax) and increased the expression of the anti-apoptotic gene (Bcl-2).