Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,661-1,670 of 1,773 results
International Journal of Molecular Sciences, 2021 • February 11, 2021
Axon growth and regeneration are cellular processes that involve signaling from the growth cone, or the site of injury back to the cell body via signaling endosomes. The understanding of cellular orga...
KEY FINDING: The endoplasmic reticulum (ER) is crucial for lipid and protein synthesis, calcium homeostasis, and acts as a platform for signaling proteins important for growth and response to injury.
J Extracell Vesicles, 2020 • October 26, 2020
The development of EV therapeutics hinges on the ability to consistently produce EVs with reliable therapeutic efficacy, necessitating well-standardized assays. Functional assays, which evaluate the e...
KEY FINDING: Functional assays are crucial for assessing the molecular and physiological effects of EV preparations on target cells, organoids, organs, or organisms.
Scientific Reports, 2021 • March 1, 2021
This study demonstrates that tacrine and duloxetine, L1 mimetic compounds, exhibit beneficial effects in the peripheral and central nervous system of demyelinated zebrafish. The observed benefits incl...
KEY FINDING: Tacrine and duloxetine promote the regeneration of oligodendrocytes in the central nervous system after oligodendrocyte ablation in zebrafish.
Frontiers in Genetics, 2021 • March 4, 2021
This study identifies a missense mutation in the ITPR1 gene in a family with hemifacial microsomia (HM). The research demonstrates that ITPR1 is involved in craniofacial development, with its expressi...
KEY FINDING: A missense mutation in the ITPR1 gene was identified in a family with HM.
Frontiers in Cellular Neuroscience, 2021 • March 8, 2021
The review summarizes the roles of endogenous estrogens, estrogen-based therapies, and estrogen-like molecules on brain homeostasis, especially regarding neurogenesis, gliogenesis, and neuroprotection...
KEY FINDING: Estrogens, including estradiol, promote survival in neurons subjected to stress conditions and may counteract aging-associated cognitive decline and prevent Alzheimer’s disease.
Frontiers in Aging Neuroscience, 2021 • March 8, 2021
This review summarizes the normal mechanism of mitochondrial quality control in axons, describes the behavior of mitochondria in axon degeneration under different conditions, and their role in axon re...
KEY FINDING: Aging is associated with mitochondrial transport, with changes in Mfn2 expression affecting mitochondrial morphology and transport in glaucoma.
Oxidative Medicine and Cellular Longevity, 2021 • March 15, 2021
This paper mainly describes the regulatory role of lncRNAs in various nervous systems and in neural differentiation of stem cells in various physiological or pathological processes. In general, more an...
KEY FINDING: lncRNAs are involved in the growth, development, and repair of the central and peripheral nervous systems.
Frontiers in Cell and Developmental Biology, 2021 • March 25, 2021
This review explores the potential of ghrelin as a therapeutic molecule for nervous system injuries. Ghrelin's ability to cross the blood-brain barrier and influence multiple physiological processes m...
KEY FINDING: Ghrelin can modulate downstream signaling cascades in both the developing and adult nervous systems, influencing neurogenesis and neuronal plasticity.
PNAS, 2000 • July 5, 2000
The study investigates the physiological function of the kinin B1 receptor by generating mice with a targeted deletion of the B1 receptor gene. These mice are healthy and normotensive but show a blunt...
KEY FINDING: B1 receptor-deficient mice exhibited blunted hypotensive response to bacterial lipopolysaccharide.
PNAS, 2001 • May 8, 2001
BMP2 alters the fate of CNS neural precursor cells from neurogenesis to astrocytogenesis. This alteration is mediated by negative HLH proteins. The findings have potential clinical applications for mi...
KEY FINDING: BMP2 reduces the number of cells expressing neuronal markers (MAP2) and markers for undifferentiated neural precursors (nestin).