Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,671-1,680 of 1,773 results
PNAS, 2001 • July 3, 2001
The study investigates the roles of BDNF and NT-4 in spinal cord sensory processing using knockout mice and an in vitro spinal cord preparation. Results show that BDNF, but not NT-4, is necessary for ...
KEY FINDING: BDNF-deficient mice showed reduced ventral root potential (VRP) evoked by stimulating nociceptive primary afferents, indicating impaired nociceptive transmission.
The Journal of Cell Biology, 2002 • October 14, 2002
This study investigates the role of Nogo-A, a neurite growth inhibitor, in peripheral nerve regeneration by expressing it in Schwann cells of transgenic mice. The key finding is that Nogo-A expression...
KEY FINDING: Expression of Nogo-A in Schwann cells significantly delays axonal regeneration in the denervated adult mouse sciatic nerve.
J Neurobiol, 2003 • January 8, 2003
This study examines the role of PDGF and FGF2 in regulating oligodendrocyte progenitor cell (OP) responses to demyelination using a murine hepatitis virus (MHV-A59) model in adult mice. The research d...
KEY FINDING: Endogenous PDGF and FGF2 stimulate the proliferation of OPs in cultures isolated during demyelination.
J Neurophysiol, 2003 • October 1, 2003
This study examines the expression and function of PACAP in the olfactory system of mice and rats, finding it present in olfactory epithelium and olfactory ensheathing cells. The study highlights diff...
KEY FINDING: PACAP immunoreactivity is present in the olfactory epithelium of neonatal, adult mice, and adult rats.
The Journal of Neuroscience, 2004 • March 24, 2004
The study reveals that DCC, a netrin-1 receptor, is present both on the neuronal surface and in intracellular pools in embryonic rat spinal commissural neurons. Netrin-1 application leads to a modest ...
KEY FINDING: Netrin-1 modestly increases cell surface DCC without activating PKA, suggesting a PKA-independent mechanism.
CMLS, Cell. Mol. Life Sci., 2004 • January 19, 2004
This study investigates the mechanisms by which olfactory ensheathing cells (OECs) promote axonal regeneration using an in vitro model of axonal injury. The findings indicate that OECs promote neurite...
KEY FINDING: OECs promote neurite sprouting after injury by acting as a physical substrate for growth.
The Journal of Neuroscience, 2004 • May 19, 2004
This study demonstrates that peripheral nerve injury leads to an increased expression of the Nav1.3 sodium channel in second-order spinal sensory neurons. The upregulation of Nav1.3 contributes to the...
KEY FINDING: Peripheral nerve injury upregulates the expression of Nav1.3 in dorsal horn nociceptive neurons, but not in astrocytes or microglia.
Phil. Trans. R. Soc. Lond. B, 2004 • April 8, 2004
This study investigates the cellular and molecular mechanisms of regeneration in Xenopus tadpoles using transgenic methods and embryonic grafting. Key findings indicate that tail regeneration occurs w...
KEY FINDING: During tail regeneration in Xenopus tadpoles, there is no evidence of de-differentiation or metaplasia; instead, tissues regenerate from their corresponding tissues in the stump.
The Journal of Neuroscience, 2004 • September 29, 2004
This study examined gene expression patterns in rat spinal cords after injury, comparing two different rat strains to understand the molecular response to SCI over time (up to 90 days). Microarray ana...
KEY FINDING: A highly orchestrated tissue repair and remodeling repertoire with a prominent cutaneous wound healing signature is conserved between two widely differing rat strains after spinal cord injury.
The Journal of Neuroscience, 2005 • February 16, 2005
This study investigates the role of STAT3 activation in conditioning injury-induced spinal axon regeneration. The researchers found that sciatic nerve transection, but not dorsal column crush, leads t...
KEY FINDING: Sciatic nerve transection induces persistent STAT3 phosphorylation in DRG neurons in vivo, while dorsal column crush does not.