Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,621-1,630 of 1,773 results
Proc. R. Soc. B, 2020 • August 26, 2020
The study demonstrates that the West African lungfish exhibits salamander-like tail regeneration, characterized by blastema formation and restoration of original tail structures. The process involves ...
KEY FINDING: Lungfish tail regeneration closely resembles that of salamanders, involving the formation of a blastema and restoration of original tail structures, including muscle, skeleton, and spinal cord.
Biomolecules, 2020 • September 15, 2020
MSC-derived exosomes can specifically target and accumulate in brain lesion sites in various murine models of diseases, where they improve the behavioral phenotype as well as reducing the inflammatory...
KEY FINDING: MSC-derived exosomes have shown therapeutic promise in various neurodegenerative disease models, leading to improvement in functional outcomes in stroke, MS, and SCI.
Brain Communications, 2019 • July 2, 2019
The study demonstrates that attenuating the DNA damage response by targeting the MRN complex is neuroprotective in models of neurodegeneration, leading to improved outcomes in Drosophila models and ma...
KEY FINDING: Genetic targeting of the MRN complex is neuroprotective in Drosophila models of neurodegeneration, suppressing the decline in climbing ability and startle response in flies expressing Ab1-42, Htt.Q128, or Tau.
Neural Regen Res, 2021 • September 22, 2020
This study investigates the combination of epidural electrical stimulation (EES) with ex vivo triple gene therapy for spinal cord injury (SCI) in rat models. The gene therapy involves transplanting ge...
KEY FINDING: Rats subjected to the combined treatment showed a limited functional improvement of the knee joint and high preservation of muscle fiber area.
Front. Cell Dev. Biol., 2020 • August 18, 2020
Neural injury in mammals often leads to persistent functional deficits as spontaneous repair in the peripheral nervous system (PNS) is often incomplete, while endogenous repair mechanisms in the centra...
KEY FINDING: Electrical stimulation of peripheral nerves elicits a retrograde calcium signal, which can be visualized in vivo using genetically encoded calcium indicators.
Frontiers in Cell and Developmental Biology, 2020 • September 8, 2020
This study explores the effects of acute and repeated caffeine exposure at different concentrations on hippocampal progenitor proliferation, integrity, and apoptosis, using an in vitro hippocampal cel...
KEY FINDING: Supraphysiological caffeine concentrations reduce progenitor integrity compared to lower caffeine doses.
eLife, 2020 • October 6, 2020
The study uses optogenetic systems, optoRaf and optoAKT, to delineate the contribution of the ERK and AKT signaling pathways to neuroregeneration in live Drosophila larvae. optoRaf or optoAKT activati...
KEY FINDING: OptoRaf or optoAKT activation enhanced axon regeneration in both regeneration-competent and -incompetent sensory neurons in the peripheral nervous system.
Neurosci. Bull., 2020 • October 13, 2020
This study explores the developmental potential of dorsally-derived oligodendrocyte progenitor cells (dOPCs) to compensate for the absence of ventrally-derived OPCs (vOPCs) in myelinating ventral axon...
KEY FINDING: In Nestin-Smo cKO mice, where ventral oligodendrogenesis is blocked, dOPCs undergo rapid amplification and spread to the ventral spinal tissue.
Front. Mol. Biosci., 2021 • March 31, 2021
This study investigates the role of microRNAs (miRNAs) in the cortex following spinal cord injury (SCI), focusing on miR-7b-3p's function in regeneration and neuroprotection. The results indicate that...
KEY FINDING: miR-7b-3p is significantly upregulated in the cortex following SCI in both young and adult mice.
G3, 2020 • October 19, 2020
The study aimed to identify genes that enhance proximal tumor formation in C. elegans glp-1(ar202) mutants using a genome-wide RNAi screen. The screen identified 43 genes whose depletion by RNAi signi...
KEY FINDING: The RNAi screen identified 43 genes that enhance proximal tumor formation in glp-1(ar202) mutants at the permissive temperature.