Therapeutic effects of syringaldehyde on spinal cord ischemia in rabbits

This study investigates the potential therapeutic effects of syringaldehyde (SA) on spinal cord ischemia (SCI) in rabbits. SCI is a condition with high morbidity and mortality. The study aims to understand if SA can reduce oxidative stress and inflammation associated with SCI. The researchers measured levels of various enzymes and substances in the spinal cord tissues of rabbits after inducing ischemia. They also examined the spinal cord tissue under a microscope to assess damage and inflammation. The results suggest that syringaldehyde therapy may reduce oxidative stress, degenerative changes, and inflammatory cell migration in the ischemic spinal cord. This indicates that SA could potentially be used as a protective agent against SCI.

• 1
  Syringaldehyde treatment significantly increased Glutathione peroxidase enzyme activity levels compared to the ischemia group.
• 2
  Histopathological analysis revealed that syringaldehyde treatment resulted in a decrease in the number of degenerated motor neurons compared to the ischemia group.
• 3
  Immunohistochemical analysis showed that syringaldehyde treatment decreased the expressions of nNOS, caspase-3, and NF-κB, which are associated with inflammation and cell death.