Genetics Research

KEY FINDING: Daily boldine administration significantly enhanced an evoked response in the tibialis anterior muscle at 2  weeks after common peroneal nerve transection.

KEY FINDING: FGF2 promotes axonal elongation and branching in cultured DRGs neurons through activation of FGFR1.

KEY FINDING: A novel frameshift insertion (c.497delinsGGATCCCCCAGCTGCATCCCCCAG: p. Ala166fs) was identified in the LDLR gene, preventing proper expression of LDLR on the cell membrane.

KEY FINDING: SCI can decrease the phosphory­lated (p)/total (t)‑GSK‑3β ratio, which leads to an increase in apoptosis, whereas treatment with GSK‑3 inhibitors can promote neurogenesis.

KEY FINDING: Hypoxic preconditioning enhances the therapeutic function of MSC-derived sEVs for IVD regeneration.

KEY FINDING: SLRPs, including chondroadherin, fibromodulin, lumican, and prolargin, are enriched in rodent and human CNS lesions but not in zebrafish.

KEY FINDING: The review found that most studies focused on histone modification and DNA methylation as epigenetic mechanisms in SCI, primarily in animal models.

KEY FINDING: DCM induces gut dysbiosis in mice, and the dysbiosis is sexually dimorphic, with more pronounced changes in male mice compared to females.

KEY FINDING: Conditional UTX deletion in endothelial cells reduces BSCB permeability, decreases inflammatory cell infiltration and ROS production, and improves neurological function recovery after SCI.

KEY FINDING: CircRNAs participate in multiple molecular mechanisms of cellular normal or pathophysiology processes, especially as miRNA sponges in the cytoplasm, activating the modulation of target genes via miRNA response elements.