Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,141-1,150 of 1,773 results
bioRxiv, 2024 • September 14, 2024
This study identifies the aryl hydrocarbon receptor (AhR) as a negative regulator of axon regeneration in DRG neurons following injury. Activation of AhR promotes stress response and inflammation at t...
KEY FINDING: AhR activation in DRG neurons inhibits axon regeneration after nerve injury.
Nature Communications, 2023 • November 21, 2023
This study introduces CRISOT, an integrated computational framework for genome-wide CRISPR off-target prediction, evaluation, and optimization, based on RNA-DNA molecular interactions derived from mol...
KEY FINDING: CRISOT outperforms existing tools with extensive in silico validations and proof-of-concept experimental validations.
Journal of Nanobiotechnology, 2023 • November 17, 2023
This study investigates the therapeutic effects of micro electric fields (EF)-induced mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) on spinal cord injury (SCI) in rats. The fin...
KEY FINDING: EF-sEVs promote functional behavioral recovery after SCI in rats, improving hindlimb movement and coordination.
Journal of Nanobiotechnology, 2023 • September 15, 2023
This study investigates the paracrine influence of pericytes on endothelial cells following SCI considering the unique association between these two cell types. Our study demonstrated that exosomal mi...
KEY FINDING: Pericyte-derived exosomes enhance endothelial cell barrier integrity in vitro.
Bioactive Materials, 2024 • January 1, 2024
This study investigates the therapeutic potential of exosomes derived from EGFR+NSCs for treating spinal cord injury (SCI). The findings demonstrate that local delivery of EGFR+NSCs-Exos promotes neur...
KEY FINDING: EGFR+NSCs-Exos can effectively promote neurite regrowth in the injury site of spinal cord-injured mice and improve their neurological function recovery.
International Journal of Biological Sciences, 2024 • January 1, 2024
This study demonstrates the depletion of the selective autophagy receptor NBR1 in NPCs during the degeneration process, leading to the buildup of SRBD1 within NPCs, thereby accelerating NPCs senescenc...
KEY FINDING: NBR1 expression is downregulated in degenerative nucleus pulposus cells (NPCs) in human and rat models of intervertebral disc degeneration (IDD).
Theranostics, 2024 • January 1, 2024
This study identifies a unique subpopulation of bone marrow mesenchymal stem cells (BMSCs), CD271+CD56+ BMSCs, with the ability to promote axon regeneration after spinal cord injury (SCI). The exosome...
KEY FINDING: CD271+CD56+ BMSC-Exos hydrogel implantation increased expression of NF and synaptophysin, markers of axon regeneration and synapse formation, respectively, in an SCI model.
AIMS Neuroscience, 2023 • November 20, 2023
This study investigated the effects of Platelet-Rich Plasma (PRP)-derived exosomes loaded with dexamethasone (Dex) on a mouse model of SCI compression. The results demonstrated that mice treated with ...
KEY FINDING: Mice treated with PRP-derived exosomes loaded with Dex (ExoDex) exhibited altered levels of TNF-α and IL-10, along with decreased Bax and increased Bcl2 expression in comparison to the model group.
Current Osteoporosis Reports, 2024 • January 10, 2024
OSM plays unique roles in regulating the maintenance and regeneration of bone, hematopoietic stem and progenitor cells, inflammation, and skeletal muscles. Dysregulated OSM production can lead to bone...
KEY FINDING: OSM regulates bone mass by stimulating osteoclast formation and promoting osteoblast commitment through the OSMR receptor.
IBRO Neuroscience Reports, 2023 • September 4, 2023
This review summarizes recent findings on the role of lipid metabolism in age-associated cognitive decline, drawing from studies in model organisms and humans. Model organisms like C. elegans, Drosoph...
KEY FINDING: Studies in C. elegans models of Alzheimer's disease suggest a neuroprotective role for the switch from glucose to lipid metabolism.