Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,121-1,130 of 1,773 results
Molecular Neurobiology, 2024 • September 6, 2023
The study investigated the role of the transcription factor Ets1 in spinal cord development and regeneration, finding it highly expressed during the embryonic period and decreasing with development. K...
KEY FINDING: Ets1 is highly expressed in the spinal cord during the embryonic period and decreases during development.
J. Biol. Chem., 2023 • September 9, 2023
The study identifies a growth-promoting amino-terminal fragment of Nogo-A that is released by proteolysis and upregulated after injury. This fragment promotes axon regeneration in vitro and interacts ...
KEY FINDING: An amino-terminal fragment of Nogo-A (aa 1-213) is produced by proteolysis near G214-N215 and its levels are increased after axotomy.
Journal of International Medical Research, 2023 • September 1, 2023
This study aimed to investigate inflammatory cytokine expression profiles in the aqueous humor (AH) of diabetic cataract (DC) patients. The multiplexed antibody assay revealed that the expression leve...
KEY FINDING: Expression levels of IL-6, sIL-6R, IL-17A, IL-8, MCP-1, TNF-b, RANTES, TIMP-1, and TIMP-2 were significantly higher in DC patients compared with ARC patients.
Cell Death and Disease, 2023 • September 5, 2023
This study investigates the role of chemokine receptor CXCR1 in inflammation-inducing experimental autoimmune encephalomyelitis (EAE) and acute respiratory distress syndrome (ARDS). The study reveals ...
KEY FINDING: CXCR1 was found to be upregulated in MS patients, and its deficiency ameliorated disease severity in EAE mice by suppressing inflammatory factor secretion.
Neural Regeneration Research, 2024 • July 20, 2023
Spinal cord injury (SCI) involves primary and secondary injuries. Secondary injuries are complex with no effective treatment developed yet, affecting neural cells and surrounding structures. Regenerat...
KEY FINDING: Stem cell-derived EVs have been shown to have many of the same regenerative properties as being MSCs, without the many challenges associated with stem cell therapy.
The Journal of Neuroscience, 2023 • November 22, 2023
This study combines retrograde tracing and scRNAseq to identify and characterize CSN subtypes based on their spinal and supraspinal projections. Machine learning tools were used to classify CSNs and l...
KEY FINDING: CSNs segregate along the forelimb and hindlimb axis and by supraspinal axon collateralization.
Regeneration, 2017 • January 18, 2017
This study investigates the role of the JAK-STAT pathway in spinal cord regeneration in Xenopus laevis, comparing regenerative and non-regenerative stages after spinal cord injury. Transcriptome analy...
KEY FINDING: Regenerative tadpoles exhibit an early and transient activation of the JAK-STAT pathway following spinal cord injury.
Microbiology Spectrum, 2023 • September 28, 2023
This study uses bibliometric analysis to summarize research trends and hotspots in the field of gut microbiota and the immune microenvironment from 1976 to 2022, using data from the Web of Science Cor...
KEY FINDING: The annual number of publications related to gut microbiota and the immune microenvironment has increased gradually, reflecting the growing interest and development in this field.
Nature Communications, 2023 • October 12, 2023
This is an author correction regarding the funding acknowledgements in the original article published in Nature Communications. The correction replaces a paragraph that incorrectly cited the Baylor-Ho...
KEY FINDING: The correction addresses an error in the acknowledgement of funding sources for genome sequencing.
Acta Biochim Biophys Sin, 2023 • October 9, 2023
This study investigates the effects of microcurrent electrical stimulation (direct/alternating current stimulation, DCS/ACS) on the behavior of primary cortical neurons using a conducting surface base...
KEY FINDING: ACS at 3 μA for 20 min significantly increases the number of neurites, axon length, and spontaneous electrical activity of neurons.