Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,111-1,120 of 1,773 results
Biomedicines, 2023 • July 18, 2023
The study compares cytokine profiles in serum and tissues of patients with and without OPLL to identify potential biomarkers and understand the mechanisms behind ossification. The research identifies ...
KEY FINDING: Serum leptin levels are significantly higher in OPLL patients compared to non-OPLL patients, suggesting it may serve as a disease marker.
eLife, 2023 • August 3, 2023
The present study showed that ALKBH5 plays a critical role in axonal regeneration after nerve injury. The ALKBH5 protein level was reduced in DRG neurons following SNC, which enhanced neurite outgrowt...
KEY FINDING: Knockdown of ALKBH5 enhanced sensory axonal regeneration, whereas overexpressing ALKBH5 impaired axonal regeneration in an m6A-dependent manner.
Theranostics, 2023 • July 24, 2023
This review highlights engineering strategies for exosomes and their delivery routes in neural research, emphasizing theranostic applications in peripheral nerve, traumatic spinal cord, and brain inju...
KEY FINDING: Engineering exosomes through pretreatment of progenitor cells can regulate their contents and enhance their bioactivity, leading to improved therapeutic outcomes in nerve regeneration.
Journal of Leukocyte Biology, 2023 • August 9, 2023
Numerous studies have demonstrated that macrophages can proliferate during homeostasis and in response to infection, injury, and disease. Macrophages proliferate in various organs and tissues, includi...
KEY FINDING: Macrophages proliferate in various organs and tissues, including skin, peritoneum, lung, heart, aorta, kidney, liver, pancreas, brain, spinal cord, eye, adipose tissue, and uterus, and in different species including mouse, rat, rabbit, and human.
Exp Neurol, 2023 • October 1, 2023
First, we have replicated that delivery of AAVrg’s can exert a wide genetic influence throughout the neuroaxis when applied rostral to an SCI lesion but that transduction efficacy within the caudal Ra...
KEY FINDING: PTEN-KO using AAVrg’s improves locomotor outcomes in both acute and chronic SCI conditions, however, the effects are severity dependent.
Nature Communications, 2023 • August 8, 2023
This study examines the role of H3K9me3 reprogramming during early development of SCNT embryos, revealing defective H3K9me3 reprogramming during SCNT embryogenesis. The researchers found that persiste...
KEY FINDING: SCNT embryos exhibit genome-wide excess H3K9me3 modification throughout preimplantation development, differing significantly from fertilized embryos.
J. Biol. Chem., 2023 • August 9, 2023
This study investigates the role of lncRNA LOC100909675 (LOC9675) in astrocyte proliferation following spinal cord injury (SCI). It finds that LOC9675 expression increases after SCI and promotes astro...
KEY FINDING: LOC9675 expression promptly increased after SCI, and reducing its expression decreased the proliferation and migration of cultured spinal astrocytes.
Nature Communications, 2023 • August 11, 2023
This study identifies Hb-egf as a neurogenic factor essential for spinal cord regeneration in zebrafish, highlighting its role in ERG cycling and neuron production. The research uncovers a TREE (hb-egf...
KEY FINDING: Hb-egfa is a neurogenic factor necessary for innate spinal cord regeneration in zebrafish.
Discover Oncology, 2023 • August 7, 2023
This study identifies Caveolin-1 (CAV1) as a key gene involved in glioma progression and resistance to oxidative phosphorylation (OXPHOS) inhibitors. The researchers found that CAV1 is highly expresse...
KEY FINDING: CAV1 is highly expressed in gliomas and its expression is positively related with pathological processes, higher CAV1 predicts shorter overall survival.
Aging Cell, 2023 • August 7, 2023
This study investigates the maturation of dormant neuronal precursors in the adult and aged brain using transgenic mice. The research questions whether the aging process affects the awakening and matu...
KEY FINDING: Dormant precursors can awaken and mature into adult-matured neurons (AM) even at old age, indicating that protracted immaturity does not prevent late awakening.