The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2

This study investigates the role of the transcription factor Ets1 in spinal cord development and axon regeneration. Ets1 was found to be highly expressed during the embryonic period and decreased during spinal cord development. Knocking down Ets1 resulted in increased axonal growth of cultured spinal cord neurons, suggesting Ets1 inhibits axon regeneration. Ets1 regulates axon growth by controlling the expression of Lcn2, identifying Ets1 as a potential therapeutic target for axon regeneration in the central nervous system.

• 1
  Ets1 is highly expressed in the spinal cord during the embryonic period and decreases during development.
• 2
  Knockdown of Ets1 significantly increased the axonal growth of cultured spinal cord neurons.
• 3
  Ets1 directly binds to the Lcn2 promoter and positively regulates Lcn2 transcription, thus regulating axon growth.