J. Biol. Chem., 2023 · DOI: https://doi.org/10.1016/j.jbc.2023.105153 · Published: August 9, 2023
Astrocyte activation and proliferation contribute to glial scar formation during spinal cord injury (SCI), which limits nerve regeneration. Long noncoding RNAs (lncRNAs) are involved in astrocyte proliferation and act as novel epigenetic regulators. The study found that lncRNA-LOC100909675 (LOC9675) expression increased after SCI, and reducing its expression decreased the proliferation and migration of spinal astrocytes. Depleting LOC9675 reduced astrocyte proliferation and facilitated axonal regrowth after SCI. The study suggests that cooperation between CTCF and LOC9675 regulates Cdk1 transcription, thereby controlling astrocyte proliferation. This provides a novel perspective on Cdk1 gene transcript regulation by lncRNA LOC9675.
Targeting LOC9675 or its interaction with CTCF could offer a novel therapeutic strategy to reduce glial scar formation and promote axonal regeneration after SCI.
The study provides new insights into the complex regulation of Cdk1, a critical cell cycle regulator, particularly in the context of astrocyte proliferation.
The research highlights the important role of lncRNAs in regulating gene expression and cellular processes in the central nervous system, particularly in response to injury.