Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,101-1,110 of 1,773 results
Cell, 2023 • July 20, 2023
The study identifies Quaking proteins (QKIs) as mRNA internal m7G binding proteins. QKI7 shuttles internal m7G-modified mRNAs into stress granules (SGs) under stress conditions, regulating mRNA metabo...
KEY FINDING: QKIs preferentially recognize internal mRNA m7G modifications.
Cells Dev, 2023 • December 1, 2023
The pharyngula stage in vertebrate development presents a seemingly uniform architecture, despite diverse cranial structures and epithelial appendages being generated. Primary axial tissues develop th...
KEY FINDING: Anterior and posterior dorsal tissues in vertebrates are generated through at least two processes that differ in both patterning and morphogenesis.
Neurospine, 2023 • June 1, 2023
Cell death pathways play a major role in SCI pathogenesis and progression. Initial tissue injury results in secondary injury, which further damages the spinal tissues chemically and mechanically, caus...
KEY FINDING: SCI pathophysiology involves blood-spinal cord barrier collapse, immune cell transmigration, and rupture of cellular axons and membranes. Key signaling pathways regulate apoptotic activity in SCI.
Scientific Reports, 2023 • July 6, 2023
This study elucidates the mechanism by which macrophages, after SCI, attract astrocytes, a critical process in glial scar formation. The research demonstrates that macrophage migration dictates the di...
KEY FINDING: Impaired macrophage migration leads to a wider distribution of reactive astrocytes and larger glial scar formation after spinal cord injury.
Cells, 2023 • June 21, 2023
This study provides a detailed characterization of the galanin (GAL) system in the human bile duct and perihilar cholangiocarcinoma (pCCA), examining the expression of GAL and its receptors (GAL1–3-R)...
KEY FINDING: GAL and GAL1-R were expressed in various bile duct cell types, GAL2-R was slightly expressed, and GAL3-R specifically in cholangiocytes and capillaries.
Cells, 2023 • June 22, 2023
This review provides a comparative analysis of spinal cord injury in both non-regenerating (mammals) and regenerating animals (axolotl, Xenopus, zebrafish), focusing on the epigenetic mechanisms under...
KEY FINDING: In mammals, axonal regrowth after a spinal cord injury is hindered by the development of a glial scar that mainly consists of reactive astrocytes and proteoglycans.
Int. J. Mol. Sci., 2023 • June 25, 2023
This study investigates the role of KDM6B in the neurogenesis potential of stem cells from the apical papilla (SCAPs) and its impact on spinal cord injury (SCI) recovery. The findings suggest that KDM...
KEY FINDING: KDM6B inhibits the expression of neural markers like NeuroD, TH, β-III tubulin, and Nestin in SCAPs.
Int. J. Mol. Sci., 2023 • June 30, 2023
This study investigates the transcription patterns of neurotrophins and their receptors in the adult zebrafish spinal cord, using qPCR and in situ hybridization techniques. The results indicate that n...
KEY FINDING: Ngf mRNA is highly expressed in the spinal cord compared with the brain, and it is the most expressed transcript in the whole adult zebrafish spinal cord, compared to other neurotrophic factors.
Neural Regeneration Research, 2023 • April 10, 2023
This study investigates the role of RhoA in dendrite degeneration and regeneration following brachial plexus injury in mice. Motor neuron-specific RhoA knockout mice were created to assess the impact ...
KEY FINDING: RhoA knockout in motor neurons attenuates dendrite degeneration after brachial plexus transection, as evidenced by higher dendrite density and reduced fragmentation in knockout mice compared to controls.
Bioactive Materials, 2023 • June 19, 2023
Neurodegenerative diseases present a growing burden on healthcare systems, necessitating effective treatments. Mesenchymal stem cells (MSCs) show promise due to their neuroregenerative, neuroprotectiv...
KEY FINDING: MSC-secretome and EVs have shown potential in improving cognitive decline, reducing plaque deposition, regulating inflammatory responses, and decreasing neuronal degeneration in Alzheimer's disease models.